Feruloylputrescine

Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research^[1].
In Vitro, Feruloylputrescine (10 µg/mL, 24 hours) can reduce FMO3 protein expression, inhibit FMO3 mRNA expression, and decrease TMA production in hepatocellular carcinoma cell lines^[1].
Feruloylputrescine (378 µM, continuously administered until muscle strip contraction stabilized) can inhibit Noradrenaline-induced urethral smooth muscle contraction^[2].
In Vivo, Feruloylputrescine (administered via diet, 10 mg per g of diet daily for 6 weeks) significantly reduces TMA and TMAO levels in high-fat diet-induced mice^[1].

References:
[1]. Hana Lee, et al. Discovery of a Novel Bioactive Compound in Orange Peel Polar Fraction on the Inhibition of Trimethylamine and Trimethylamine N-Oxide through Metabolomics Approaches and In Vitro and In Vivo Assays: Feruloylputrescine Inhibits Trimethylamine via Suppressing cntA/B Enzyme. J Agric Food Chem. 2024 Apr 10;72(14):7870-7881.
[2]. Nakase K, et al. Effects of pollen-extract components, diamines and derivatives of feruloylputrescine on isolated bladder and urethral smooth muscles of mice. Jpn J Pharmacol. 1990 Jun;53(2):157-64.

Feruloylputrescine 是一种具有口服活性的存在于柑橘类植物中的酚酰胺，通过 L-精氨酸脱羧形成。Feruloylputrescine 抑制单加氧酶 (cntA) 和还原酶 (cntB) 以及三甲胺的产生。Feruloylputrescine 可用于代谢疾病与心血管疾病研究。
在体外，Feruloylputrescine (10 µg/mL, 24 小时) 可减少 FMO3 蛋白表达，抑制 FMO3 mRNA 的表达，减少肝癌细胞系中的 TMA 生成^[1]。
Feruloylputrescine (378 µM, 持续给药至肌条带收缩反应稳定) 可抑制 Noradrenaline 诱导的尿道平滑肌收缩^[2]。
在体内，Feruloylputrescine (经饮食送服，每日每 g 饮食含 10 mg Feruloylputrescine，共 6 周) 可显著减少高脂饮食诱导的小鼠中 TMA 和 TMAO 水平^[1]。