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Erythromycin A enol ether Sale

(Synonyms: 红霉素 A 烯醇醚) 目录号 : GC12263

A mimic of motilin

Erythromycin A enol ether Chemical Structure

Cas No.:33396-29-1

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Erythromycin A enol ether, also known as 8,9-anhydroerythromycin A 6,9 hemiketal, is a kind of catabolite of erythromycin A without its antibiotic properties.

Erythromycin A enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. Erythromycin A enol ether is also the agent of gastrointestinal (GI) distress [1].

Motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. Motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. Motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. Besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.

In Vitro: No data available.

In Vivo: No data available.

Clinical trial: No data available.

Reference:
[1] Steinmetz W E, Shapiro B L, Roberts J J, et al.  The structure of erythromycin enol ether as a model for its activity as a motilide.[J]. Journal of Medicinal Chemistry, 2002, 45(22): 4899-4902.

Chemical Properties

Cas No. 33396-29-1 SDF
别名 红霉素 A 烯醇醚
化学名 8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin
Canonical SMILES O=C1[C@@H]([C@H]([C@@H]([C@]([H])([C@]2(CC(C)=C([C@@H]([C@H]([C@@](C)([C@H](O1)CC)O)O)C)O2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@@](C)(C4)OC)O)C)[H])C
分子式 C37H65NO12 分子量 715.9
溶解度 ≤30mg/ml in DMSO;15mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.3968 mL 6.9842 mL 13.9684 mL
5 mM 0.2794 mL 1.3968 mL 2.7937 mL
10 mM 0.1397 mL 0.6984 mL 1.3968 mL
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