Dihydralazine sulfate
(Synonyms: 硫酸双肼屈嗪, Dihydralazine sulphate, Depressan, Hydralazine sulfate, 1,4-Dihydrazinophthalazine sulfate, Nepresol) 目录号 : GC20103
Dihydralazine sulfate 是一种抗高血压的药物。
Cas No.:7327-87-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Dihydralazine sulphate is an antihypertensive agent.
| Cas No. | 7327-87-9 | SDF | |
| 别名 | 硫酸双肼屈嗪, Dihydralazine sulphate, Depressan, Hydralazine sulfate, 1,4-Dihydrazinophthalazine sulfate, Nepresol | ||
| 分子式 | C8H12N6O4S | 分子量 | 288.28 |
| 溶解度 | DMSO: 6 mg/mL(20.8 mM) | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4688 mL | 17.3442 mL | 34.6885 mL |
| 5 mM | 0.6938 mL | 3.4688 mL | 6.9377 mL |
| 10 mM | 0.3469 mL | 1.7344 mL | 3.4688 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dihydralazine sulfate analysis using 2-methyl-o-nitropyridine-6-carboxaldehyde
J Pharm Sci 1977 Jan;66(1):116-8.PMID:833726DOI:10.1002/jps.2600660132.
A sensitive, selective colorimetric assay was developed for the quantitative analysis of Dihydralazine sulfate. The method is based on the interaction of buffered (pH 4) Dihydralazine sulfate with a methanolic solution of 2-methyl-3-nitropyridine-6-carboxaldehyde upon heating to give an orange color. This color can be quantified spectrophotometrically at 450 nm,with a lower limit of detection of 1 mug/ml. The color is stable for at least 24 hr. There is no interference from other drugs likely to be present along with Dihydralazine sulfate and common excipients. The method was used successfully for the determination of Dihydralazine sulfate in combination with other drugs in different commercial tablets. The developed method was applicable as a stability-indicating assay.
Flow-injection chemiluminescence determination of Dihydralazine sulfate in serum using luminol and diperiodatocuprate (III) system
Spectrochim Acta A Mol Biomol Spectrosc 2010 Jan;75(1):77-82.PMID:19910243DOI:10.1016/j.saa.2009.09.044.
A novel flow-injection chemiluminescence (CL) method for the determination of Dihydralazine sulfate (DHZS) is described. The method is based on the reaction of luminol and diperiodatocuprate (K(2)[Cu(H(2)IO(6))(OH)(2)], DPC) in alkaline medium to emit CL, which is greatly enhanced by DHZS. The possible CL mechanism was first proposed based on the kinetic characteristic, CL spectrum and UV spectra. The optimum condition for the CL reaction was in detail studied using flow-injection system. The experiments indicated that under optimum condition, the CL intensity was linearly related to the concentration of DHZS in the range of 7.0x10(-9) to 8.6x10(-7) g mL(-1) with a detection limit (3sigma) of 2.1x10(-9) g mL(-1). The proposed method had good reproducibility with the relative standard deviation 3.1% (n=7) for 5.2x10(-8) g mL(-1) of DHZS. This method has the advantages of simple operation, fast response and high sensitivity. The special advantage of the system is that very low concentration of luminol can react with DPC catalyzed by DHZS to get excellent experiment results. And CL cannot be observed nearly when luminol with same concentration reacts with other oxidants, so luminol-DPC system has higher selectivity than other luminol CL systems. The method has been successfully applied to determine DHZS in serum.
Chemiluminescence investigation of carbon dioxide-enhanced oxidation of Dihydralazine sulfate by peroxynitrite and its application to pharmaceutical analysis
Anal Chim Acta 2008 Jun 2;616(2):190-5.PMID:18482603DOI:10.1016/j.aca.2008.04.032.
A weak chemiluminescence (CL) emission was observed upon mixing peroxynitrite (ONOO(-)) with Dihydralazine sulfate (DHZS). Further experiments showed that carbonate media could enhance the CL emission significantly. Based on these observations, a novel flow injection CL method for the determination of DHZS is developed. The CL signal is linearly with DHZS concentration in the range of 0.01-3.0 microg mL(-1) with a detection limit of 3.6 ng mL(-1). The method was applied to the analysis of DHZS in pharmaceutical preparations and compared well with the high-performance liquid chromatography (HPLC) method. The CL mechanism is discussed and it is postulated that it involves nitrosoperoxocarboxylate (ONOOCO(2)(-)), which is an unstable adduct and can rapidly decompose into *NO(2) and *CO(3)(-) radical. The latter can then oxidize DHZS to give out strong CL emission.