Deltamethrin
(Synonyms: 溴氰菊酯,Decamethrin) 目录号 : GC60128
A type II pyrethroid insecticide and Nav channel modulator
Cas No.:52918-63-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1 It activates Nav1.8 channels and induces a tail current delay in Xenopus oocytes expressing the rat channel when used at a concentration of 10 ?M. Deltamethrin induces mortality in A. sinensis (LC50 = 4.522 ppm) and T. urticae (LC50 = 0.06 g/L).2,3 It decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats when administered at a dose of 5 mg/kg.4 Formulations containing deltamethrin have been used as domestic and agricultural insecticides.
1.Choi, J.S., and Soderlund, D.M.Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytesToxicol. Appl. Pharmacol.211(3)233-244(2006) 2.Chang, K.-S., Yoo, D.-H., Shin, E.-H., et al.Susceptibility and resistance of field populations of Anopheles sinensis (Diptera: Culicidae) collected from Paju to 13 insecticidesOsong Public Health Res. Perspect.4(2)76-80(2013) 3.Penman, D.R., Chapman, R.B., and Bowie, M.H.Direct toxicity and repellent activity of pyrethroids against Tetranychus urticae (Acari: Tetranychidae)J. Econ. Entomol.79(5)1183-1187(1986) 4.Abdallah, F.B., Slima, A.B., Dammak, I., et al.Comparative effects of dimethoate and deltamethrin on reproductive system in male miceAndrologia42(3)182-186(2010)
| Cas No. | 52918-63-5 | SDF | |
| 别名 | 溴氰菊酯,Decamethrin | ||
| Canonical SMILES | O=C([C@H]1C(C)(C)[C@H]1/C=C(Br)\Br)O[C@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2 | ||
| 分子式 | C22H19Br2NO3 | 分子量 | 505.2 |
| 溶解度 | DMSO: ≥ 100 mg/mL (197.94 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9794 mL | 9.8971 mL | 19.7941 mL |
| 5 mM | 0.3959 mL | 1.9794 mL | 3.9588 mL |
| 10 mM | 0.1979 mL | 0.9897 mL | 1.9794 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Deltamethrin toxicity: A review of oxidative stress and metabolism
Environ Res 2019 Mar;170:260-281.PMID:30599291DOI:10.1016/j.envres.2018.12.045.
Deltamethrin is widely used worldwide due to its valuable insecticidal activity against pests and parasites. Increasing evidence has shown that Deltamethrin causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. For the first time, this review systematically summarizes the Deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltamethrin-mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress. Further, Deltamethrin metabolism, including metabolites, metabolic enzymes and pathways and Deltamethrin metabolite toxicity are discussed. This review will shed new light on Deltamethrin toxicity mechanisms and provide effective strategies to ensure pest control and prevention of human and animal poisoning.
Trypsin-catalyzed Deltamethrin degradation
PLoS One 2014 Mar 3;9(3):e89517.PMID:24594869DOI:10.1371/journal.pone.0089517.
To explore if trypsin could catalyze the degradation of non-protein molecule Deltamethrin, we compared in vitro hydrolytic reactions of Deltamethrin in the presence and absence of trypsin with ultraviolet-visible (UV/Vis) spectrophotometry and gas chromatography-mass spectrometry (GC/MS). In addition, acute oral toxicity of the degradation products was determined in Wistar rats. The results show that the absorption peak of Deltamethrin is around 264 nm, while the absorption peaks of Deltamethrin degradation products are around 250 nm and 296 nm. In our GC setting, the retention time of undegraded Deltamethrin was 37.968 min, while those of Deltamethrin degradation products were 15.289 min and 18.730 min. The LD50 of Deltamethrin in Wistar rats is 55 mg/kg, while that of Deltamethrin degradation products is 3358 mg/kg in female rats and 1045 mg/kg in male rates (61-fold and 19-fold reductions in toxicity), suggesting that trypsin could directly degrade Deltamethrin, which significantly reduces the toxicity of Deltamethrin. These results expand people's understanding of the functions of proteases and point to potential applications of trypsin as an attractive agent to control residual pesticides in the environment and on agricultural products.
Deltamethrin: uses and environmental safety
Rev Environ Contam Toxicol 1992;124:1-18.PMID:1732993DOI:10.1007/978-1-4612-2864-6_1.
Deltamethrin is a photostable pyrethroid providing valuable insecticidal activity against a large number of pests. Since it has potential uses for crop, cattle, and human health protection, extensive research work was done to evaluate its safety. Protection against insect pests in agriculture requires safety not only for applicators, but also for honey bees, nontarget insects and other arthorpods, mammals and birds in the wild and terrestrial fauna. Protection against vectors of harmful or endemic diseases involves direct treatment of waters with resulting risks for aquatic fauna. Extensive preharvest and postharvest use of a single pesticide demands thorough knowledge of residues on each crop and how they are affected by food processing. These various topics were considered in order to assess the safety of this new insecticide.
Deltamethrin transformation by Bacillus thuringiensis and the associated metabolic pathways
Environ Int 2020 Dec;145:106167.PMID:33035892DOI:10.1016/j.envint.2020.106167.
The biological toxicity of Deltamethrin at molecular level has been investigated, whereas, the proteome responsive mechanisms of cells under Deltamethrin stress at the phylogenetic level are not clear. The proteome expression, transformation-related pathway and regulatory network of Bacillus thuringiensis during the process of Deltamethrin transformation were explored using proteomics and metabolomics approaches in the present study. The results showed that Deltamethrin was effectively removed by B. thuringiensis within 48 h. The stress responses of B. thuringiensis were activated to resist Deltamethrin stress, with significant differential expression of proteins that were primarily involved in the synthesis of DNA and shock proteins, endospore formation, carbon metabolism. The expression patterns of ribosomal proteins confirmed that the transcription and translation of DNA, and biosynthesis of heat shock proteins were inhibited as Deltamethrin transformation. The synthesis of oxaloacetate and acetyl-CoA were also hindered, resulting in downregulated expression of carbohydrate metabolism, TCA cycle and energy metabolism. Meanwhile, endospore formation and germination were promoted to resist oxidative stress induced by Deltamethrin. These findings imparted novel insight to elucidate underlying stress response mechanisms of the organism under target contaminants stress, and the interaction between Deltamethrin transformation and cellular metabolism at the pathway and network levels.
Transcriptome analysis provides insight into deltamethrin-induced fat accumulation in 3T3-L1 adipocytes
Pestic Biochem Physiol 2022 Jun;184:105114.PMID:35715053DOI:10.1016/j.pestbp.2022.105114.
Previously, Deltamethrin (a Type-II pyrethroid) has been reported to increase triglyceride (fat) accumulation in adipocytes, while its underlying molecular mechanism is not fully determined. The aim of this study was to further investigate the molecular mechanisms of Deltamethrin induced fat accumulation in murine 3T3-L1 adipocytes. Consistent to previous reports, Deltamethrin (10 μM) significantly promoted adipogenesis in 3T3-L1 adipocytes. RNA sequencing (RNA-seq) results showed that 721 differentially expressed genes (DEGs) were identified after Deltamethrin treatment, involving in 58 Functional groups of Gene Ontology (GO) and 255 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Several key functional groups regulating adipogenesis, such as fat cell differentiation (Igf1, Snai2, Fgf10, and Enpp1) and cytosolic calcium ion concentration (Nos1, Cxcl1, and Ngf) were significantly enriched. Collectively, these results suggest that the promotion of adipogenesis by Deltamethrin was attributed to an obesogenic global transcriptomic response, which provides further understanding of the underlying mechanisms of deltamethrin-induced fat accumulation.