Dehydroacetic acid sodium
(Synonyms: 脱氢醋酸钠,Sodium dehydroacetate) 目录号 : GC62924
Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
Cas No.:4418-26-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
| Cas No. | 4418-26-2 | SDF | |
| 别名 | 脱氢醋酸钠,Sodium dehydroacetate | ||
| 分子式 | C8H7NaO4 | 分子量 | 190.13 |
| 溶解度 | DMSO : 38mg/mL | 储存条件 | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2596 mL | 26.2978 mL | 52.5956 mL |
| 5 mM | 1.0519 mL | 5.2596 mL | 10.5191 mL |
| 10 mM | 0.526 mL | 2.6298 mL | 5.2596 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dehydroacetic acid sodium salt stability in cosmetic preservative mixtures
Int J Cosmet Sci 1988 Feb;10(1):29-32.PMID:19456908DOI:10.1111/j.1467-2494.1988.tb00582.x.
Synopsis Dehydroacetic acid sodium salt Prevan (DHANa) stability in presence of other cosmetic preservatives as Bronopol, Germall 115 and Kathon CG was investigated through a HPLC method that permits simultaneous determination of binary and ternary mixtures of the above preservatives. A new molecule coresponding to 3,7-dimethyl-1H, 9H, 10H, dipyrano (4,3-b: 3',4'-e) pyran-1, 9-dione has been discovered to be spontaneously formed between DHA and free or released formaldehyde. Its structure has been established by means of elemental analysis, NMR and mass spectrometry aswell as its chromatographic and antimicrobial behaviour. The magnesium salt present as stabilizer in the Kathon CG solution can also cause the formation of insoluble magnesium salt from DHANa. The ascertained chemical interaction among these preservatives is therefore discussed as a function of their cosmetic application.
Controlled release of Dehydroacetic acid sodium salt for the stability improvement of cosmetic formulations*
Int J Cosmet Sci 1994 Jun;16(3):105-12.PMID:19250491DOI:10.1111/j.1467-2494.1994.tb00088.x.
Synopsis The kinetics of decomposition of the sodium salt of dehydroacetic acid (DHA.Na) in presence of formaldehyde and formaldehyde donors was investigated. The possibility of preparing systems capable of providing the cosmetic preparation with increasing amounts of DHA.Na corresponding to portions interacted with formaldehyde was explored. Data relevant to matrices prepared from ethylcellulose and polyethylene by casting and moulding process, respectively, are reported and discussed. Experimental data demonstrate the possibility of preparing polymeric systems able to control in terms of rate and duration the relase of DHA.Na, according to time and concentration needs of a typical cosmetic formulation.
Active packaging for topical cosmetic/drug products: a hot-melt extruded preservative delivery device
Eur J Pharm Biopharm 2010 Jun;75(2):291-6.PMID:20304050DOI:10.1016/j.ejpb.2010.03.007.
A delivery device intended for the prolonged release of antimicrobial agents, able to enhance the stability profile of liquid/semi-solid cosmetic/pharmaceutical products for topical application, was proposed in the present study. With the aid of a simulation program based on compartment models, the relevant kinetic and formulation parameters were defined using Dehydroacetic acid sodium salt (DHA.Na, Prevan) as the model preservative. Indeed, the overall DHA.Na degradation rate is increased in the presence of formaldehyde releasers that are often employed as co-preservatives. Inert matrices (3 g weight and 18 mm diameter) based on high-density polyethylene (HDPE), possibly consistent with the design of an active packaging meant for preservative delivery, were prepared by hot-melt extrusion. Units with satisfactory physical-technological properties could be obtained up to 50%w/w loads of antimicrobial agent. In an attempt to modify the relevant Fickian release profiles by varying the area exposed to the medium, matrix systems coated with an impermeable film except for one base (CMs) or for the inner surface of a central drilled hole (PCMs) were investigated. On the basis of the n exponent of power equation and the outcome of linear fitting, PCMs were proven able to yield the zero-order release behaviour needed to ensure constant DHA.Na levels over a predetermined time period, as indicated by the simulation process.