CSF1R Protein, Human
目录号 : GC27027CSF1R蛋白普遍存在于单核吞噬细胞，特别是巨噬细胞和单核细胞中，并参与多种生物过程。它响应 IL34 和 CSF1 诱导促炎趋化因子的释放，有助于先天免疫和炎症。CSF1R 蛋白, Human (HEK293, His-Fc) 是重组的 CSF1R 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。
Sample solution is provided at 25 µL, 10mM.
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CSF1R蛋白普遍存在于单核吞噬细胞，特别是巨噬细胞和单核细胞中，并参与多种生物过程。它响应 IL34 和 CSF1 诱导促炎趋化因子的释放，有助于先天免疫和炎症。CSF1R 蛋白, Human (HEK293, His-Fc) 是重组的 CSF1R 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。
CSF1R 蛋白尤其存在于巨噬细胞和单核细胞等单核吞噬细胞中，参与多种生物过程。它响应 IL34 和 CSF1 促进促炎趋化因子的释放，有助于先天免疫和炎症过程。此外，CSF1R 对于调节破骨细胞增殖和分化、骨吸收、正常骨骼和牙齿发育至关重要。它也是男性和女性正常生育能力以及怀孕期间乳腺中乳管和腺泡结构发育所必需的。
| Purity | Greater than 95% as determined by reducing SDS-PAGE. | Source | HEK293 |
| Phycical Appearance | Lyophilized powder. | Shipping Condition | |
| Synonyms | CSF1R 蛋白; HEK293, His-Fc; Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS | ||
| Amino Acid Sequence | IPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDE | ||
| Apparent Molecular Weight | 115-125 kDa | ||
| Stability | Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | ||
| Biological Activity |
1. Measured by its ability to inhibit the M-CSF-induced proliferation of M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 1.402 ng/mL in the presence of 1 ng/mL of Recombinant Human M-CSF. corresponding to a specific activity is 7.133×105 units/mg. 2. Loaded CSF1R Protein, Human (HEK293, His-Fc) on HIS1K biosensor, can bind Axatilimab with an affinity constant of 1.467E-11 M as determined in BLI assay. |
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| Endotoxin Level | <1 EU/μg, determined by LAL method. | ||
| Reconstitution | It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose). | ||
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. | ||
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, His-Fc) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The CSF1R protein, particularly found in mononuclear phagocytes like macrophages and monocytes, is involved in various biological processes. It promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes. Additionally, CSF1R is crucial for regulating osteoclast proliferation and differentiation, bone resorption, normal bone and tooth development. It is also required for normal fertility in both males and females, as well as for the development of milk ducts and acinar structures in the mammary gland during pregnancy.
1. Measured by its ability to inhibit the M-CSF-induced proliferation of M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 1.402 ng/mL in the presence of 1 ng/mL of Recombinant Human M-CSF. corresponding to a specific activity is 7.133×105 units/mg.
2. Loaded CSF1R Protein, Human (HEK293, His-Fc) on HIS1K biosensor, can bind Axatilimab with an affinity constant of 1.467E-11 M as determined in BLI assay.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.