Creatine
(Synonyms: 肌酸) 目录号 : GC33777
Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
Cas No.:57-00-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
[1] Liangliang Ji, et al. Immunity. 2019 Aug 20;51(2):272-284.e7
| Cas No. | 57-00-1 | SDF | |
| 别名 | 肌酸 | ||
| Canonical SMILES | O=C(O)CN(C)C(N)=N | ||
| 分子式 | C4H9N3O2 | 分子量 | 131.14 |
| 溶解度 | Water : 16.67 mg/mL (127.12 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.6254 mL | 38.1272 mL | 76.2544 mL |
| 5 mM | 1.5251 mL | 7.6254 mL | 15.2509 mL |
| 10 mM | 0.7625 mL | 3.8127 mL | 7.6254 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Creatine, Creatine Kinase, and Aging
Subcell Biochem 2018;90:145-168.PMID:30779009DOI:10.1007/978-981-13-2835-0_6.
With an ever aging population, identifying interventions that can alleviate age-related functional declines has become increasingly important. Dietary supplements have taken center stage based on various health claims and have become a multi-million dollar business. One such supplement is Creatine, a major contributor to normal cellular physiology. Creatine, an energy source that can be endogenously synthesized or obtained through diet and supplement, is involved primarily in cellular metabolism via ATP replenishment. The goal of this chapter is to summarize how Creatine and its associated enzyme, Creatine kinase, act under normal physiological conditions, and how altered levels of either may lead to detrimental functional outcomes. Furthermore, we will focus on the effect of aging on the Creatine system and how supplementation may affect the aging process and perhaps reverse it.
Effects of Creatine Supplementation on Brain Function and Health
Nutrients 2022 Feb 22;14(5):921.PMID:35267907DOI:10.3390/nu14050921.
While the vast majority of research involving Creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on Creatine and the brain. Preliminary studies indicate that Creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain Creatine content in humans. Furthermore, Creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to Creatine supplementation on total Creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to Creatine supplementation on brain Creatine uptake, assess the impact of Creatine on cognition with a focus on sleep deprivation, discuss the effects of Creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on Creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion.
Creatine Use in Sports
Sports Health 2018 Jan/Feb;10(1):31-34.PMID:29059531DOI:10.1177/1941738117737248.
Context: The use of Creatine as a dietary supplement has become increasingly popular over the past several decades. Despite the popularity of Creatine, questions remain with regard to dosing, effects on sports performance, and safety. Evidence acquisition: PubMed was searched for articles published between 1980 and January 2017 using the terms Creatine, Creatine supplementation, sports performance, and dietary supplements. An additional Google search was performed to capture National Collegiate Athletic Association-specific Creatine usage data and US dietary supplement and Creatine sales. Study design: Clinical review. Level of evidence: Level 4. Results: Short-term use of Creatine is considered safe and without significant adverse effects, although caution should be advised as the number of long-term studies is limited. Suggested dosing is variable, with many different regimens showing benefits. The safety of Creatine supplementation has not been studied in children and adolescents. Currently, the scientific literature best supports Creatine supplementation for increased performance in short-duration, maximal-intensity resistance training. Conclusion: While Creatine appears to be safe and effective for particular settings, whether Creatine supplementation leads to improved performance on the field of play remains unknown.
Creatine and creatinine metabolism
Physiol Rev 2000 Jul;80(3):1107-213.PMID:10893433DOI:10.1152/physrev.2000.80.3.1107.
The goal of this review is to present a comprehensive survey of the many intriguing facets of Creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology. Very recently, a series of new discoveries have been made that are bound to have distinguished implications for bioenergetics, physiology, human pathology, and clinical diagnosis and that suggest that deregulation of the Creatine kinase (CK) system is associated with a variety of diseases. Disturbances of the CK system have been observed in muscle, brain, cardiac, and renal diseases as well as in cancer. On the other hand, Cr and Cr analogs such as cyclocreatine were found to have antitumor, antiviral, and antidiabetic effects and to protect tissues from hypoxic, ischemic, neurodegenerative, or muscle damage. Oral Cr ingestion is used in sports as an ergogenic aid, and some data suggest that Cr and creatinine may be precursors of food mutagens and uremic toxins. These findings are discussed in depth, the interrelationships are outlined, and all is put into a broader context to provide a more detailed understanding of the biological functions of Cr and of the CK system.
Common questions and misconceptions about Creatine supplementation: what does the scientific evidence really show?
J Int Soc Sports Nutr 2021 Feb 8;18(1):13.PMID:33557850DOI:10.1186/s12970-021-00412-w.
Supplementing with Creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that Creatine supplementation produces a variety of beneficial effects in older and patient populations. Furthermore, evidence-based research shows that Creatine supplementation is relatively well tolerated, especially at recommended dosages (i.e. 3-5 g/day or 0.1 g/kg of body mass/day). Although there are over 500 peer-refereed publications involving Creatine supplementation, it is somewhat surprising that questions regarding the efficacy and safety of Creatine still remain. These include, but are not limited to: 1. Does Creatine lead to water retention? 2. Is Creatine an anabolic steroid? 3. Does Creatine cause kidney damage/renal dysfunction? 4. Does Creatine cause hair loss / baldness? 5. Does Creatine lead to dehydration and muscle cramping? 6. Is Creatine harmful for children and adolescents? 7. Does Creatine increase fat mass? 8. Is a Creatine 'loading-phase' required? 9. Is Creatine beneficial for older adults? 10. Is Creatine only useful for resistance / power type activities? 11. Is Creatine only effective for males? 12. Are other forms of Creatine similar or superior to monohydrate and is Creatine stable in solutions/beverages? To answer these questions, an internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding Creatine supplementation.