Clodinafop-propargyl
(Synonyms: 炔草酯) 目录号 : GC61762
Clodinafop-propargyl是一种芳基苯氧基丙酸类除草剂，可用于防治一年生禾本科植物的出苗，包括Avena,Lolium,Setaria,PhalarisandAlopecurusspp。
Cas No.:105512-06-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp[1].
[1]. Wenbi Guan, et al. Dissipation of clodinafop-propargyl and its metabolite in wheat field ecosystem. Bull Environ Contam Toxicol. 2013 Jun;90(6):750-5.
| Cas No. | 105512-06-9 | SDF | |
| 别名 | 炔草酯 | ||
| Canonical SMILES | C[C@@H](OC1=CC=C(OC2=NC=C(Cl)C=C2F)C=C1)C(OCC#C)=O | ||
| 分子式 | C17H13ClFNO4 | 分子量 | 349.74 |
| 溶解度 | DMSO: 100 mg/mL (285.93 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8593 mL | 14.2963 mL | 28.5927 mL |
| 5 mM | 0.5719 mL | 2.8593 mL | 5.7185 mL |
| 10 mM | 0.2859 mL | 1.4296 mL | 2.8593 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Peer review of the pesticide risk assessment of the active substance clodinafop (variant evaluated Clodinafop-propargyl)
EFSA J 2020 Jul 7;18(7):e06151.PMID:32665791DOI:10.2903/j.efsa.2020.6151.
The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Greece, and co-rapporteur Member State, Germany, for the pesticide active substance Clodinafop-propargyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Clodinafop-propargyl as a herbicide on wheat, rye and triticale. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified. The European Commission mandated EFSA to reconsider the acceptable operator exposure level (AOEL) setting and to update the non-dietary exposure assessment if needed.
Dissipation of Clodinafop-propargyl and its metabolite in wheat field ecosystem
Bull Environ Contam Toxicol 2013 Jun;90(6):750-5.PMID:23612716DOI:10.1007/s00128-013-0997-4.
The dissipation and residues of Clodinafop-propargyl and clodinafop in wheat and soil were investigated by high performance liquid chromatography-tandem mass spectrometry. Clodinafop-propargyl rapidly degraded to the acid derivative-clodinafop as major metabolite in plant and soil. The half-lives of Clodinafop-propargyl were 2.35-11.20 days in soil and 6.00 days in wheat plant. The half-lives of clodinafop were 7.04-11.22 days in soil and 0.67-1.24 days in wheat plant. The residues of Clodinafop-propargyl and clodinafop in wheat grain, wheat straw and soil were below the detection limit.
Peer review of the pesticide risk assessment of the active substance clodinafop (variant evaluated Clodinafop-propargyl)
EFSA J 2018 Nov 16;16(11):e05467.PMID:32625749DOI:10.2903/j.efsa.2018.5467.
The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Greece and co-rapporteur Member State Germany for the pesticide active substance Clodinafop-propargyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Clodinafop-propargyl as a herbicide on wheat, rye and triticale. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.
Freezing stress affects the efficacy of Clodinafop-propargyl and 2,4-D plus MCPA on wild oat (Avena ludoviciana Durieu) and turnipweed [Rapistrum rugosum (L.) All.] in wheat (Triticum aestivum L.)
PLoS One 2022 Oct 6;17(10):e0274945.PMID:36201477DOI:10.1371/journal.pone.0274945.
The occurrence of freezing stress around herbicides application is one of the most important factors influencing their performance. This experiment was performed to evaluate the efficacy of Clodinafop-propargyl and 2,4-D plus MCPA (2,4-Dichlorophenoxyacetic acid plus 2-methyl-4-chlorophenoxyacetic acid), the most important herbicides used in wheat fields in Iran, under the influence of a freezing treatment (-4°C). Wheat and its two common weeds, winter wild oat (Avena ludoviciana Durieu) and turnipweed [Rapistrum rugosum (L.) All.], were exposed to the freezing treatment for three nights from 7:00 P.M. to 5:00 A.M. before and after herbicide application, and their response was compared with plants that did not grow under freezing stress. Under no freezing (NF) and freezing after spray (FAS) conditions, winter wild oat was completely controlled with the recommended dose of Clodinafop-propargyl (64 g ai ha-1; hereafter g ha-1). However, the survival percentage of winter wild oat in the freezing before spray (FBS) of Clodinafop-propargyl 64 g ha-1 was 7%, and it was completely controlled with twice the recommended dose (128 g ha-1). Under NF conditions and FAS treatment, turnipweed was completely controlled with twice the recommended dose of 2,4-D plus MCPA (2025 g ae ha-1; hereafter g ha-1), while there was no complete control under recommended rate. However, in the FBS treatment, the survival of turnipweed was 7% under double dose. The LD50 (dose required to control 50% of individuals in the population) and GR50 (dose causing 50% growth reduction of plants) rankings were NF
Waterborne exposure to Clodinafop-propargyl disrupts the posterior and ventral development of zebrafish embryos
Environ Toxicol Chem 2011 Jul;30(7):1576-81.PMID:21495064DOI:10.1002/etc.549.
Clodinafop-propargyl, an aryloxyphenoxypropionate herbicide, is widely used for the control of annual grasses. However, research focusing on the ecotoxicity of this herbicide is limited. The present study employed zebrafish (Danio rerio) as a model to investigate its developmental toxicity. Embryos were exposed to a range of concentrations from 0.2 µM to 5 µM starting at late cleavage stage (2 h postfertilization, [hpf]) or late gastrulation stage (10 hpf). The results showed that the two exposure strategies had the same minimum teratogenic concentration of 0.6 µM but caused different groups of morphogenetic malformations. When exposure was initiated at 2 hpf, Clodinafop-propargyl caused various embryonic phenotypes, including embryos with a fin gap in the ventral tail and embryos with coiled tail. When exposure was initiated at 10 hpf, Clodinafop-propargyl resulted in failure of the tail to detach, in which the ventral tissues failed to grow out but instead adhered to the yolk extension, and the defect differed to various degrees among embryos. Similar effects were observed for embryos exposed to clodinafop, the metabolite of Clodinafop-propargyl. Because these defects were mainly confined to the posterior and ventral region that derived from ventral blastoderm cells, we have evaluated the expression of the ventral mesoderm marker gene gata-1 and ventral ectoderm marker gene gata-3. No significant alteration was seen in gata-1 expression except for the expanded blood islands, whereas the expression of gata-3 was significantly reduced. Our findings showed that Clodinafop-propargyl exposure disturbed embryonic patterning and fate specification of ventrally derived gastrula ectoderm cells.