Cholesterol glucuronide
目录号 : GC62896Cholesterol glucuronide 是一种由 UDP 葡萄糖醛酸转移酶在肝脏中产生的脂质的内源性代谢产物。
Cas No.:17435-78-8
Sample solution is provided at 25 µL, 10mM.
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Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase[1][2].
The content of Cholesterol glucuronide in the normal liver is higher than the reported value for plasma (18 μg/g vs 6 μg/mL). Cholesterol glucuronide is synthesized in the liver and some of it enters the bloodstream. Probably the rest goes into the bile, like the other glucuronides[1].
[1]. Hara A, et al. Isolation and determination of cholesterol glucuronide in human liver. Lipids. 1982 Aug;17(8):515-8.
[2]. Wade AP. The estimation of cholesterol sulphate and cholesterol glucuronide in plasma. Clin Chim Acta. 1970 Jan;27(1):109-16.
Cas No. | 17435-78-8 | SDF | |
分子式 | C33H54O7 | 分子量 | 562.78 |
溶解度 | 储存条件 | ||
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1 mg | 5 mg | 10 mg | |
1 mM | 1.7769 mL | 8.8845 mL | 17.7689 mL |
5 mM | 0.3554 mL | 1.7769 mL | 3.5538 mL |
10 mM | 0.1777 mL | 0.8884 mL | 1.7769 mL |
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2.
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Abnormalities in cerebral lipids and hepatic Cholesterol glucuronide of a patient with GM1-gangliosidosis type 2
Adv Exp Med Biol 1982;152:291-305.PMID:7136918doi
The brain tissue of a patient with GM1-gangliosidosis Type 2 showed an abnormal distribution pattern of lipids, that is, a marked increase in GM1-ganglioside, asialo-GM1 and cholesterol ester, a significant increase of glucosylceramide, lactosylceramide and asialo-GM2, and a decrease in galactocerebroside and sulfatide. On the other hand, the liver tissue showed a normal pattern of glycolipids, that is, the presence of normal amounts of glucosylceramide, lactosylceramide, globotriaosylceramide, globoside, hematoside (GM3) and GD3. However, it was found that the patient's liver contained a larger amount of Cholesterol glucuronide than normal liver and that it was present only in the liver and not in the other tissues. This represents the first report of elevated Cholesterol glucuronide in liver of GM1-gangliosidosis.