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Chlorotrianisene Sale

(Synonyms: 氯丁烯二烯) 目录号 : GC10012

A synthetic non-steroidal estrogen

Chlorotrianisene Chemical Structure

Cas No.:569-57-3

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5 mg
¥1,350.00
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10 mg
¥2,250.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Description:

ED50: 2.0 μM

Glandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. This induction appears to be mediated by increased gene expression since glandular kallikrein mRNA is also estrogen-induced. Chlorotrianisene is classified as an estrogen agonist.

In vitro: The ED50 of chlorotrianisene were lowered by 3.9-fold. Chlorotrianisene inhibited the growth of both P388 and P388/ADR cells in a concentration-dependent manner [1].

In vivo: Chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. On uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. Chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on PRL or the uterus. Further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2].

Clinical trial: Chlorotrianisene is a estrogen which is highly effective in the suppression of postpartum lactation when given orally in dosage of 48 mg/day for seven days. Recurrence of symptoms and appearance of withdrawal bleeding are virtually eliminated, probably because of the storage of chlorotrianisene in the body fat and its gradual release after cessation of therapy [3].

Reference:
[1] Ramu A, Glaubiger D, Fuks Z.  Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues. Cancer Res. 1984 Oct;44(10):4392-5.
[2] Powers CA, Hatala MA, Pagano PJ.  Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. Mol Cell Endocrinol. 1989 Sep;66(1):93-100.
[3] NULSEN RO, CARMON WB, HENDRICK HO.  TACE (chlorotrianisene), a new estrogen for inhibition of lactation. Am J Obstet Gynecol. 1953 May;65(5):1048-51.

Chemical Properties

Cas No. 569-57-3 SDF
别名 氯丁烯二烯
化学名 4,4',4''-(2-chloroethene-1,1,2-triyl)tris(methoxybenzene)
Canonical SMILES COC1=CC=C(/C(C2=CC=C(OC)C=C2)=C(Cl)/C3=CC=C(OC)C=C3)C=C1
分子式 C23H21ClO3 分子量 380.86
溶解度 ≥ 16.1mg/mL in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.6256 mL 13.1282 mL 26.2564 mL
5 mM 0.5251 mL 2.6256 mL 5.2513 mL
10 mM 0.2626 mL 1.3128 mL 2.6256 mL
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