Chlorfenapyr
(Synonyms: 虫螨腈) 目录号 : GC60106
A pyrrole pro-insecticide
Cas No.:122453-73-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chlorfenapyr is a pyrrole pro-insecticide that is metabolized in vivo into CL 303268 by mixed function oxidases.1 Chlorfenapyr increases respiratory activity in German cockroaches when used at concentrations ranging from 1 to 10 ?g per insect but has no effect on respiration in Sf9 cells when used at concentrations ranging from 1 to 100 ?M and does not affect respiration in isolated rat liver mitochondria up to a concentration of 10 ?M. Chlorfenapyr is active against a variety of insects including those susceptible and resistant to pyrethroid and organophosphate insecticides, including horn flies (H. irritans) as well as A. culicifacies and A. stephensi mosquitos that carry malaria (LC50s = 2-2.39% suspension impregnated on paper).2,3 Chlorfenapyr is lethal to rats with LD50 values of 441 and 1,152 mg/kg for male and female rats, respectively.1 Formulations containing chlorfenapyr have been used to control termites and in agriculture to control various insects.
1.Black, B.C., Hollingworth, R.M., Ahammadsahib, K.I., et al.Insecticidal action and mitochondrial uncoupling activity of AC-303,630 and related halogenated pyrrolesPestic. Biochem. Physiol.50(2)115-128(1994) 2.Sheppard, D.C., and Joyce, J.A.Increased susceptibility of pyrethroid-resistant horn flies (Diptera: Muscidae) to chlorfenapyrJ. Econ. Entomol.91(2)398-400(1998) 3.Raghavendra, K., Barik, T.K., Sharma, P., et al.Chlorfenapyr: A new insecticide with novel mode of action can control pyrethroid resistant malaria vectorsMalar. J.1016(2011)
| Cas No. | 122453-73-0 | SDF | |
| 别名 | 虫螨腈 | ||
| Canonical SMILES | N#CC1=C(C2=CC=C(Cl)C=C2)N(COCC)C(C(F)(F)F)=C1Br | ||
| 分子式 | C15H11BrClF3N2O | 分子量 | 407.61 |
| 溶解度 | DMSO: 250 mg/mL (613.33 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4533 mL | 12.2666 mL | 24.5333 mL |
| 5 mM | 0.4907 mL | 2.4533 mL | 4.9067 mL |
| 10 mM | 0.2453 mL | 1.2267 mL | 2.4533 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A fatal case of Chlorfenapyr poisoning and a review of the literature
J Int Med Res 2022 Sep;50(9):3000605221121965.PMID:36112969DOI:10.1177/03000605221121965.
Background: Chlorfenapyr is a widely used pesticide and is classified as moderately hazardous to human health. Ingestion usually leads to mortality in humans. However, Chlorfenapyr toxicity has a variable course and mechanism of action.Case presentation: We report the case of a 79-year-old female who ingested Chlorfenapyr with the intent to commit suicide. The liquid was ingested 2 hours before she was brought to our emergency department. Gastric lavage was immediately performed. On admission, laboratory examinations revealed mildly elevated liver enzyme and creatinine kinase levels. Acute fever occurred on day 7; on day 8, the patient died of progressive respiratory distress and conscious disturbance. Chlorfenapyr toxicity leads to high rates of mortality (75%) and causes damage to the liver and the nervous system. Conclusions: It is necessary to observe patients with Chlorfenapyr toxicity for 3 weeks because no significant abnormalities occur in the early phase. The onset of fever and deterioration of consciousness is a warning sign of a sudden fatal outcome. We review the literature and discuss neurologic and cardiopulmonary impairment in the clinical course of Chlorfenapyr poisoning.
[Two cases of acute Chlorfenapyr poisoning and literature review]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 Mar 20;40(3):212-216.PMID:35439865DOI:10.3760/cma.j.cn121094-20210721-00366.
In recent years, Chlorfenapyr poisoning has gradually increased in clinical practice, but the case fatality rate remains high. At present, the research on its poisoning mechanism and clinical characteristics is limited, and there is no effective treatment. In order to summarize the clinical characteristics of Chlorfenapyr poisoning, in order to guide the clinical treatment, this article reported 2 cases of acute chlorfenayr poisoning and 21 cases of literature review, and summarized the clinical characteristics of Chlorfenapyr poisoning.Most of the symptoms of gastrointestinal symptoms, profuse sweating, high fever, and changes in consciousness after Chlorfenapyr poisoning, and delayed exacerbations are common, which can involve multiple organ systems such as the central nervous system, providing a basis for clinical diagnosis and treatment.
Experience in the treatment of Chlorfenapyr poisoning
J Toxicol Sci 2023;48(4):221-225.PMID:37005280DOI:10.2131/jts.48.221.
In China, the extensive use of the pesticide Chlorfenapyr has led to an increase in Chlorfenapyr poisoning. However, there are limited reports on Chlorfenapyr poisoning, and most of them are fatal cases. This study retrospectively analyzed four patients admitted to the emergency room after Chlorfenapyr intake and detected different concentrations of Chlorfenapyr in their plasma. Among them, one patient died and three patients survived. Case 1 suffered respiratory and circulatory failure with a deep coma shortly after oral administration of 100 mL of a the chlorfenapyr-containing mixture and died 30 min after admission. Case 2 experienced transient nausea and vomiting after oral administration of Chlorfenapyr (50 mL). The patient had normal laboratory results and was discharged with no further treatment. Case 3 developed nausea and vomiting and a light coma after taking 30 mL of Chlorfenapyr orally. He underwent blood perfusion and plasma exchange in the intensive care unit (ICU) and was discharged with recovery. A two-week follow-up visit, however, revealed hyperhidrosis. Case 4 (advanced age with severe underlying disease) developed a light coma after oral intake of 30 mL of Chlorfenapyr. Subsequently, pulmonary infection and gastrointestinal bleeding were developed. The patient experienced blood perfusion and mechanical ventilation in the ICU and finally survived after treatment. The present study provides the basic information, plasma concentration of toxins, onset of poisoning and treatment process of the four patients mentioned above, providing novel insights into the clinical diagnosis and treatment of Chlorfenapyr poisoning.
Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review
Korean J Radiol 2016 Mar-Apr;17(2):277-80.PMID:26957914DOI:10.3348/kjr.2016.17.2.277.
Chlorfenapyr is a widely used, moderately hazardous pesticide. Previous reports have indicated that Chlorfenapyr intoxication can be fatal in humans. We reported the first non-fatal case of chlorfenapyr-induced toxic leukoencephalopathy in a 44-year-old female with resolution of extensive and abnormal signal intensities in white matter tracts throughout the brain, brain stem, and spinal cord on serial magnetic resonance imaging.
[Vigilance against a highly lethal insecticide Chlorfenapyr poisoning (report of 4 cases and literature review)]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Sep 20;39(9):689-693.PMID:34624954DOI:10.3760/cma.j.cn121094-20210513-00251.
In order to improve the clinical attention to the poisoning of Chlorfenapyr, the diagnosis and treatment strategy of Chlorfenapyr poisoning were discussed. This paper collected 4 cases of Chlorfenapyr in the emergency department of the Second Hospital of Hebei Medical University and 4 cases of literature review, summarized the clinical characteristics of pesticide poisoning cases containing Chlorfenapyr in China, and summarized and analyzed the clinical data of the cases. Seven of the 8 patients died from poisoning by Chlorfenapyr. Exposure to Chlorfenapyr through respiratory tract and digestive tract showed high mortality. Fever, hyperhidrosis, elevated muscle enzymes and progressive central nerve damage were its prominent clinical characteristics. Most of the initial symptoms of exposure were not serious. Some patients, especially those with low exposure dose, had a relatively stable stage with or without clinical diagnosis and treatment. In case of sweating, obvious fever and disturbance of consciousness, the condition would deteriorate rapidly, respiratory and circulatory failure and eventually die. With the increase of production capacity and market launch, people have more opportunities to be exposed to Chlorfenapyr. It is urgent to strengthen the basic and clinical research of Chlorfenapyr poisoning; Attention should be paid to the observation and treatment in the initial stable stage of poisoning, which can be used as a reference for the treatment of oxidative phosphoric acid dissolving coupling agent (sodium pentachlorophenol) poisoning.