Chloramine-T
(Synonyms: 氯胺) 目录号 : GC30169
A common reagent
Cas No.:127-65-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chloramine-T is a common reagent in a variety of synthetic processes.1 It has been used as a reagent in aminohydroxylation and allylic amination reactions, as a nitrogen source for the aziridination of alkenes and olefins, and in the deprotection of thio groups in sulfur-containing compounds, among others. It has been used as a reagent in the synthesis of Factor Xa inhibitors.2 Chloramine-T (0.2% w/v) is also an antiseptic agent that is bactericidal against S. epidermidis, S. aureus, E. faecalis, E. coli, P. mirabilis, and E. cloacae.3
1.Agnihotri, G.Chloramine-T (sodium N-chloro-p-toluenesulfonamide)Synlett182857-2858(2005) 2.Lam, P.Y.S., Clark, C.G., Li, R., et al.Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulantsJ. Med. Chem.46(21)4405-4418(2003) 3.Fuursted, K., Hjort, A., and L., K.Evaluation of bactericidal activity and lag of regrowth (postantibiotic effect) of five antiseptics on nine bacterial pathogensJ. Antimicrob. Chemother.40(2)221-226(1997)
| Cas No. | 127-65-1 | SDF | |
| 别名 | 氯胺 | ||
| Canonical SMILES | O=S(C1=CC=C(C)C=C1)(N([Na])Cl)=O | ||
| 分子式 | C7H7ClNNaO2S | 分子量 | 227.64 |
| 溶解度 | Water : ≥ 41 mg/mL (180.11 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3929 mL | 21.9645 mL | 43.929 mL |
| 5 mM | 0.8786 mL | 4.3929 mL | 8.7858 mL |
| 10 mM | 0.4393 mL | 2.1965 mL | 4.3929 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Iron(II)-chloramine-T reaction
Talanta 1973 Jan;20(1):65-71.18961239 10.1016/0039-9140(73)80232-2
When a large excess of the oxidant is used in the iron(II)-chloramine-T reaction at pH 2.56-5.6 the amount of oxidant consumed is well above the stoichiometric amount required to oxidize iron(II) to iron(III). This has been attributed to the formation and subsequent behaviour of free radicals during the reaction. The formation of free radicals has been experimentally demonstrated. They apparently dimerize to give products of the type R-NCl-NCl-R (R = CH(3)C(6)H(4)SO(2)), which are further oxidized by Chloramine-T. The dimerized species liberate iodine very slowly from acidified potassium iodide. This explanation satisfactorily accounts for the observed extent and rate of destruction of excess of Chloramine-T in presence of small amounts of Fe(II) or bromide at pH 2.65-4.70. The storage of Chloramine-T in metal containers might cause extensive destruction of the oxidant by a similar free radical mechanism and should be avoided.
Chloramine-T application for Trichodina sp. in Arapaima gigas juveniles: Acute toxicity, histopathology, efficacy, and physiological effects
Vet Parasitol 2022 Mar;303:109667.35124292 10.1016/j.vetpar.2022.109667
Trichodinids are problematic ectoparasites for intensive arapaima fish farming, which can make their breeding costly and unprofitable. The search for effective and safe therapeutic molecules is constant, and Chloramine-T has stood out as an effective biocide to treat various pathogens in aquaculture. Here we investigated the acute toxicity (LC50-4h) of Chloramine-T and its behavioural, morphological, histological, physiological, and antiparasitic effects on the control of trichodinids in arapaima juveniles. Initially arapaima were exposed to Chloramine-T (0, 10, 20, 40, 50, 60, 80, 100 mg L-1) for 4 h. During this period, behavioural, morphological, and mortality changes were recorded. Immediately after a toxicity test, gills were collected for the histological analysis. The LC50-4h was calculated at 23.8 mg L-1 of Chloramine-T. Behavioural changes like erratic swimming, loss of balance, gasping at the water surface, excessive mucus, jumping at the water surface, lethargy and gill hyperventilation, and morphological changes like loss of scales, ocular opacity, and skin darkening, were considered mild in arapaima exposed to 10 and 20 mg L-1 of Chloramine-T for 4 h. The arapaima gills exposed to 10, 20 and, 40 mg L-1 of Chloramine-T presented epithelial hyperplasia, dilated venous sinus and eosinophilic infiltrate, but they were reversible and of a low pathological degree. Based on the acute toxicity test (LC50-4h) results, concentrations were defined for the in vivo efficacy test, during which arapaima were exposed to 0, 10, 15, and 20 mg L-1 of Chloramine-T for 1 h. After a therapeutic bath, physiological and parasitological analyses were performed. The use of 20 mg L-1 of Chloramine-T significantly reduced (p < 0.05) parasitism by Trichodina sp. with an efficacy of 50.27 % and 53.23 % in gills and on the body surface, respectively. Chloramine-T did not change haematological parameters (erythrogram and thrombogram) or the biochemical parameters of arapaima after 1 h of exposure. However, monocytosis and neutrophilia were noted at slightly higher concentrations (15 and 20 mg L-1), but changes in fish homeostasis were not characterised. Thus, we demonstrate that the application of a therapeutic bath with 20 mg L-1 of Chloramine-T for 1 h reduces parasitism by trichodinids and does not affect general arapaima juvenile health.
Pretreatment Method for Chloramine-T Decon Sample Before GC Analysis of HD and VX
Bull Environ Contam Toxicol 2022 Nov;109(5):859-864.36065028 10.1007/s00128-022-03612-5
Chloramine-T, especially its solution in weak acidity, is one of the decontaminants for chemical warfare agents (CWAs), HD, and VX. A high CWAs recovery from decontamination (decon) sample via pretreatment was essential for evaluating decontamination effects. This paper performed experiments to optimize pretreatment methods to extract residual CWAs from Chloramine-T decon samples before GC analysis. Effects of two neutralization methods, destroying decon activity by 15% Na2SO3 or decreasing decon activity by 3% NH3·H2O or 4% NaOH, were studied. Results showed they were all suitable for the HD decon sample, but only 4% NaOH was ideal for the VX decon sample. As for extractant, compared with dichloromethane, petroleum ether was more suitable for recovering CWAs from decon samples. A high recovery above 80% could be obtained for HD and VX samples ranging from 10 mg/L to 10,000 mg/L when optimized neutralization and extraction methods were simultaneously carried out.
Chloramine-T-Mediated Oxidation of Benzylic Alcohols Using Indium(III) Triflate
Chem Pharm Bull (Tokyo) 2017;65(8):801-804.28768934 10.1248/cpb.c17-00061
The efficient oxidation of benzylic alcohols to carbonyl compounds was performed using Chloramine-T and a catalytic amount of indium(III) triflate. The primary benzylic alcohols were converted to the corresponding aldehydes in a good yield, and the secondary benzylic alcohols were oxidized to ketones in a high yield. The optimized reaction conditions required 0.3 eq of indium(III) triflate and the use of acetonitrile as a solvent.
3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
Molecules 2021 Jun 8;26(12):3491.34201335 PMC8227129
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using Chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of Chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.