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Cefazolin Sale

(Synonyms: 头孢唑啉,Cephazolin) 目录号 : GC60683

Cefazolin(Cephazolin) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Cefazolin Chemical Structure

Cas No.:25953-19-9

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10mM (in 1mL DMSO)
¥594.00
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100mg
¥540.00
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产品描述

Cefazolin(Cephazolin) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Chemical Properties

Cas No. 25953-19-9 SDF
别名 头孢唑啉,Cephazolin
Canonical SMILES O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O
分子式 C14H14N8O4S3 分子量 454.51
溶解度 DMSO: 250 mg/mL (550.04 mM) 储存条件 4°C, away from moisture
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1 mM 2.2002 mL 11.0009 mL 22.0017 mL
5 mM 0.44 mL 2.2002 mL 4.4003 mL
10 mM 0.22 mL 1.1001 mL 2.2002 mL
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Research Update

Cefazolin

Ann Intern Med 1978 Nov;89(5 Pt 1):650-6.PMID:362999DOI:10.7326/0003-4819-89-5-650.

After 5 years of use, Cefazolin can be considered similar to cephalothin as a therapeutic agent and in its potential for adverse reactions. When Cefazolin and cephalothin are compared by appropriately designed clinical trials, neither Cefazolin's slightly greater in-vitro susceptibility to staphylococcal beta-lactamase inactivation, nor its slightly greater microbiologic activity for some enterobacteraciae has been shown to result in any readily apparent therapeutic differences. The important differences between Cefazolin and cephalothin--and this is also probably true with respect to cephapirin and cephradine--are not in therapeutic effectiveness, microbiologic activity, or toxicity but rather in pharmacokinetics and cost-effectiveness.

Cefazolin-induced hypoprothrombinemia

Am J Health Syst Pharm 2008 May 1;65(9):823-6.PMID:18436729DOI:10.2146/ajhp070243.

Purpose: A case of cefazolin-induced hypoprothrombinemia in a patient with renal failure is reported. Summary: A 50-year-old African-American woman was transferred from the orthopedics service to the internal medicine service for management of acute renal failure. Before her transfer, she had spinal surgery and subsequently developed a wound infection complicated by Escherichia coli bacteremia. After trials of multiple antibiotics, she developed acute interstitial nephritis and renal failure. On the day of her transfer to the internal medicine service, i.v. Cefazolin sodium 1 g was administered every 24 hours to eradicate the E. coli detected in blood cultures. Her baseline International Normalized Ratio (INR) was 1.3. On day 7 of Cefazolin therapy, her INR increased to 4.0. Because of her recent history of bleeding and hypotension, vitamin K 10 mg i.v. was administered, followed by 5 mg orally for the next two days. Her INR decreased and normalized at 1.1. The patient had no changes to other drug therapies and had no medical conditions known to independently affect prothrombin time during this episode. The score on the Naranjo et al. adverse-event probability scale revealed a probable relationship between Cefazolin and hypoprothrombinemia in this patient. Conclusion: A patient with a postsurgery wound infection and acute renal failure developed hypoprothrombinemia after receiving Cefazolin for seven days.

A quality assurance initiative on improving Cefazolin perioperative redose compliance

Int J Qual Health Care 2022 Oct 8;34(4):mzac073.PMID:36103371DOI:10.1093/intqhc/mzac073.

Objective: Compliance with perioperative antibiotic prophylaxis is crucial for preventing surgical site infection. Anesthesiologists can play a significant role in reducing surgical site infections by following clinical practice guidelines for antibiotic prophylaxis and redosing during surgery. A quality assurance initiative was implemented at a tertiary hospital with the goal of improving Cefazolin perioperative antibiotic compliance. Design: This was a retrospective observational study. Setting: Main operating room of a tertiary care teaching hospital in New York, USA. Our main operating room includes 22 operating rooms that incorporates surgeries from general surgery, vascular surgery, neurology, gynecology, urology, orthopedics, ear, nose and throat (ENT) etc. Participants: All cases in the main operating room from March 1, 2018 to March 31, 2021 that received first dose of Cefazolin and in which the duration of surgery was more than 4 hrs. Intervention: A multifaceted intervention was initiated to address low compliance with Cefazolin redosing. Multifaceted interventions included the development of a perioperative antibiotic guide for anesthesia providers, automated reminders in anesthesia electronic medical records, grand rounds education, survey and email communications, and regular feedback reports to the anesthesia department. Main outcome measures: Cefazolin perioperative redose compliance rate. Results: Rates of redose compliance were examined in three time periods: preintervention, intervention and postintervention. Cefazolin redosing compliance was 58% in the preintervention period and 90% in the postintervention period. There was a significant positive change in the trend of compliance during the intervention period, indicating that the odds of compliance increased by 13% per month in the intervention period compared to the preintervention period (odds ratio = 1.13, P < 0.001). Redose compliance improvements were sustained a year after the postintervention period (an average of 91%). Surgical site infection rates for colon, coronary artery bypass graft and hip surgeries did not show any significant trend during these time periods. Conclusion: Multifaceted interventions led to significant and sustained improvements in Cefazolin redosing compliance in the main operating room of a tertiary hospital.

Cefazolin pharmacokinetics in cats under surgical conditions

J Feline Med Surg 2017 Oct;19(10):992-997.PMID:27609113DOI:10.1177/1098612X16666594.

Objectives The aim of this study was to determine the plasma pharmacokinetic profile, tissue concentrations and urine elimination of Cefazolin in cats under surgical conditions after a single intravenous dose of 20 mg/kg. Methods Intravenous Cefazolin (20 mg/kg) was administered to nine young mixed-breed cats 30 mins before they underwent surgical procedures (ovariectomy or orchiectomy). After antibiotic administration, samples from blood, some tissues and urine were taken. Cefazolin concentrations were determined in all biological matrices and pharmacokinetic parameters were estimated. Results Initial plasma concentrations were high (Cp(0), 134.80 ± 40.54 µg/ml), with fast and moderately wide distribution (distribution half-life [t½(d)] 0.16 ± 0.15 h; volume of distribution at steady state [V(d[ss])] 0.29 ± 0.10 l/kg) and rapid elimination (body clearance [ClB], 0.21 ± 0.06 l/h/kg; elimination half-life [t½], 1.18 ± 0.27 h; mean residence time 1.42 ± 0.36 h). Thirty to 60 mins after intravenous administration, Cefazolin tissue concentrations ranged from 9.24 µg/ml (subcutaneous tissue) to 26.44 µg/ml (ovary). The tissue/plasma concentration ratio ranged from 0.18 (muscle) to 0.58 (ovary). Cefazolin urine concentrations were high with 84.2% of the administered dose being eliminated in the first 6 h postadministration. Conclusions and relevance Cefazolin plasma concentrations remained above a minimum inhibitory concentration of ⩽2 µg/ml up to 4 h in all the studied cats. This suggests that a single intravenous dose of 20 mg/kg Cefazolin would be adequate for perioperative prophylactic use in cats.

Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Clin Ther 2018 Apr;40(4):664-667.PMID:29496321DOI:10.1016/j.clinthera.2018.02.009.

Purpose: The aim was to investigate the stability of Cefazolin in elastomeric infusion devices. Methods: Elastomeric devices (Infusor LV) that contain Cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of Cefazolin. Samples were also assessed for changes in pH, solution color, and particle content. Findings: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions. Implications: These findings will allow the administration of Cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.