CD39 Protein, Human (sf9, His)
目录号 : GC27206CD39蛋白是神经系统中的重要调节因子，通过水解ATP和其他核苷酸来协调嘌呤能神经传递。其酶活性可将血小板活化的ADP水解成AMP，从而有效阻止血小板聚集。
Sample solution is provided at 25 µL, 10mM.
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CD39蛋白是神经系统中的重要调节因子，通过水解ATP和其他核苷酸来协调嘌呤能神经传递。其酶活性可将血小板活化的ADP水解成AMP，从而有效阻止血小板聚集。CD39 蛋白, Human (sf9, His) 是重组的 CD39 蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。
在神经系统中，CD39 蛋白通过水解 ATP 和其他核苷酸，充当嘌呤能神经传递的关键调节剂。其酶活性延伸至预防血小板聚集，因为它能有效地将血小板活化的 ADP 水解为 AMP。值得注意的是，CD39 在水解 ATP 和 ADP 方面表现出同等的能力，强调了其在调节嘌呤能信号通路以及促进神经传递和血小板功能的复杂调节方面的多功能作用。
| Purity | Greater than 90% as determined by reducing SDS-PAGE. | Source | Sf9 insect cells |
| Phycical Appearance | Solution. | Shipping Condition | Shipping with dry ice. |
| Synonyms | CD39 蛋白; Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-apyrase; CD39; Entpd1 | ||
| Apparent Molecular Weight | Approximately 56.7 kDa | ||
| Stability | Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles. | ||
| Biological Activity | 1. Measured by its ability to hydrolyze the 5’-phosphate groups from the substrate adenosine-5’-triphosphate (ATP) and the specific activity is >5000 pmol/min/µg. 2. Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His) with an affinity constant of 3.546E-09 M as determined in BLI assay. Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His) with an affinity constant of 3.546E-09 M as determined in BLI assay. | ||
| Endotoxin Level | <1 EU/μg, determined by LAL method. | ||
| Formulation | Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.1. Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips. | ||
The CD39 protein is an important regulator in the nervous system, coordinating purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic ability can hydrolyze platelet-activated ADP into AMP, thereby effectively preventing platelet aggregation. CD39 Protein, Human (sf9, His) is the recombinant human-derived CD39 protein, expressed by Sf9 insect cells , with C-His labeled tag. In the nervous system, the CD39 protein serves as a key regulator of purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic activity extends to the prevention of platelet aggregation, as it efficiently hydrolyzes platelet-activating ADP to AMP. Notably, CD39 exhibits equal proficiency in the hydrolysis of both ATP and ADP, emphasizing its versatile role in modulating purinergic signaling pathways and contributing to the intricate regulation of neurotransmission and platelet function.
1. Measured by its ability to hydrolyze the 5’-phosphate groups from the substrate adenosine-5’-triphosphate (ATP) and the specific activity is >5000 pmol/min/µg. 2. Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His) with an affinity constant of 3.546E-09 M as determined in BLI assay. Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His) with an affinity constant of 3.546E-09 M as determined in BLI assay.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.