Benzofurodil (Benfurodil)
(Synonyms: 琥珀苯呋地尔,Benfurodil; CB4091; Eudilat) 目录号 : GC32624苯并呋地尔(Benfurodil)是一种强心剂,用于慢性充血性心力衰竭的治疗。
Cas No.:3447-95-8
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Benzofurodil is a cardiotonic, which is used for the chronic treatment of congestive heart failure.
Benzofurodil (Benfurodil hemisuccinate) is a Cardiotonic[1]. The synthetic drug Benzofurodil (Benfurodil hemisuccinate) which is used for the chronic treatment of congestive heart failure[2].
[1]. Mao F, et al. Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs. Molecules. 2016 Jan 12;21(1):75. [2]. JohnBoukouvalas, et al. Facile access to 4-aryl-2(5H)-furanones by Suzuki cross coupling: Efficient synthesis of rubrolides C and E. Tetrahedron Lett. 1998 Oct 15: 7665-7668.
Cas No. | 3447-95-8 | SDF | |
别名 | 琥珀苯呋地尔,Benfurodil; CB4091; Eudilat | ||
Canonical SMILES | O=C(OC(C1=C(C)C2=CC(C3=CC(OC3)=O)=CC=C2O1)C)CCC(O)=O | ||
分子式 | C19H18O7 | 分子量 | 358.34 |
溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.7906 mL | 13.9532 mL | 27.9065 mL |
5 mM | 0.5581 mL | 2.7906 mL | 5.5813 mL |
10 mM | 0.2791 mL | 1.3953 mL | 2.7906 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[High-pressure liquid chromatographic determination of Benfurodil hemisuccinate in blood and urine (author's transl)]
J Chromatogr 1979 Oct 11;164(2):195-203.PMID:541410doi
A sensitive and reliable method for quantitative determination of Benfurodil hemisuccinate and Benfurodil in plasma by high-pressure liquid chromatography on a Zorbax SIL column with a mean particle size of 7 micrometer and UV detection at 254 nm is described. Benfurodil hemisuccinate is stable in plasma but not in aqueous solutions. This is explained by its great fixation to plasma proteins which has been shown by equilibrium dialysis.