Argipressin acetate (113-79-1(free base))

Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.
In vitro, Vasopressin stimulate NKCC2 phosphorylation increase mediated by cAMP-PKA and Ca(2+) signaling in the colon.The expression and phosphorylation of NKCC2 are increased in the colon by vasopressin stimulation, in association with enhanced activity of the vasopressin/cAMP and Ca(2+) pathways^[1].

References:
[1].Xue H , Tang X . Effect of vasopressin on Na+–K+–2Cl cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon[J]. European Journal of Pharmacology, 2016, 771:241-246.
[2].Yao Y , Fu L Y , Zhang X , et al. Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons[J]. AJP Regulatory Integrative and Comparative Physiology, 2012, 302(7):R815-24.

Vasopressin acetate (113-79-1(free base)) 是一种具有血管收缩和抗利尿活性的肽激素，可与血管精氨酸加压素受体 V1 结合，在 A7r5 大鼠主动脉平滑肌细胞和新生大鼠心肌细胞中的 Kd 值分别为 1.31 和 1.44 nM。
在体外，Vasopressin 通过cAMP-PKA和Ca(2+)信号途径在结肠中促进NKCC2的磷酸化水平增加。通过 Vasopressin 刺激，结合 Vasopressin /cAMP和Ca(2+)途径的活性增强，NKCC2在结肠中的表达和磷酸化水平得到上调^[1]。