Anti-Mouse/Rat IL-17A Antibody (17F3)
目录号 : GC27301Anti-Mouse/Rat IL-17A Antibody (17F3) 是一种源自小鼠的 IgG1κ 型抗体抑制剂，靶向小鼠和大鼠 IL-17A。Anti-Mouse/Rat IL-17A Antibody (17F3) 可中和 IL-17。Anti-Mouse/Rat IL-17A Antibody (17F3) 可用于感染、免疫和代谢性疾病的研究，如胞内分枝杆菌感染和糖尿病。
Sample solution is provided at 25 µL, 10mM.
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Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes[1][2][3].
In Vivo, Anti-Mouse/Rat IL-17A Antibody (17F3) (100 μg, i.p., every other day for 11 days) shows potent anti-infective effective in M.intracellulare-infected mice models[1].
Anti-Mouse/Rat IL-17A Antibody (17F3) (0.5 mg/dose, i.p., 3 times/week) reduces autoimmune infiltrates in immune checkpoint inhibitor (ICI)-treated mice models[2].
Anti-Mouse/Rat IL-17A Antibody (17F3) (200 μg, i.p., twice weekly until week 12) is protective against diabetic nephropathy in streptozotocin -induced diabetic mice[3].
References:
[1]. Jung BG, et al. Early IL-17A production helps establish Mycobacterium intracellulare infection in mice. PLoS Pathog. 2022 Apr 1;18(4):e1010454.
[2]. Lechner MG, et al. Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy. J Immunol. 2022 Aug 15;209(4):696-709.
[3]. Ma J, et al. Interleukin 17A promotes diabetic kidney injury. Sci Rep. 2019 Feb 19;9(1):2264.
Anti-Mouse/Rat IL-17A Antibody (17F3) 是一种源自小鼠的 IgG1κ 型抗体抑制剂，靶向小鼠和大鼠 IL-17A。Anti-Mouse/Rat IL-17A Antibody (17F3) 可中和 IL-17。Anti-Mouse/Rat IL-17A Antibody (17F3) 可用于感染、免疫和代谢性疾病的研究，如胞内分枝杆菌感染和糖尿病。
在体内，Anti-Mouse/Rat IL-17A Antibody (17F3) (100 μg，腹腔注射，两天一次，持续 11 天) 在胞内分枝杆菌感染的小鼠模型中显示出强大的抗感染效果[1]。
Anti-Mouse/Rat IL-17A Antibody (17F3) (0.5 mg/dose，腹腔注射，每周 3 次) 可减少免疫检查点抑制剂 (ICI) 治疗的小鼠模型中的自身免疫浸润[2]。
Anti-Mouse/Rat IL-17A Antibody (17F3) (200 μg，腹腔注射，每周两次，直至第 12 周) 对链脲佐菌素诱导的糖尿病小鼠的糖尿病肾病具有保护作用[3]。
| Animal Model: | M.intracellulare-infected mice models (C57BL/6, female, 6-8 weeks)[1] |
| Dosage: | 100 μg |
| Administration: | Intraperitoneally injection, every other day for 11 days |
| Result: | Reduced IL-17A levels and increased IL-4 and IL-22 levels. Decreased the date rate of infectious mice. Reduced bacteria. Significantly reduced subsequent granulomatous and fibrotic changes in the lungs. Increased the number of DCs and NK cells in the lungs. Reduced MMP-3 production. |
References:
[1]. Jung BG, et al. Early IL-17A production helps establish Mycobacterium intracellulare infection in mice. PLoS Pathog. 2022 Apr 1;18(4):e1010454.
| Cas No. | SDF | ||
| 分子式 | 分子量 | 150 kDa | |
| 溶解度 | 储存条件 | Store at 4°C for 2 years, do not freeze. | |
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.7 μL | 33.3 μL | 66.7 μL |
| 5 mM | 1.3 μL | 6.7 μL | 13.3 μL |
| 10 mM | 0.7 μL | 3.3 μL | 6.7 μL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
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Purity: >95.00%
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