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Amorolfine HCl Sale

(Synonyms: 盐酸阿莫罗芬; Ro 14-4767/002) 目录号 : GC15052

An antifungal

Amorolfine HCl Chemical Structure

Cas No.:78613-38-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO) 待询 待询
100mg
¥494.00
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200mg
¥810.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Amorolfine hydrochloride (Ro 14-4767/002) is a antifungal reagent.Target: AntifungalAmorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species [1]. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. Simultaneous addition of amorolfine resulted in a significant increase in killing at all concentrations. This increase was not significantly enhanced by either preincubation of neutrophils or blastospores for 2 h with the drug [2].

References:
[1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.
[2]. Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

Chemical Properties

Cas No. 78613-38-4 SDF
别名 盐酸阿莫罗芬; Ro 14-4767/002
化学名 (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride
Canonical SMILES CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
分子式 C21H36ClNO 分子量 353.97
溶解度 Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.8251 mL 14.1255 mL 28.251 mL
5 mM 0.565 mL 2.8251 mL 5.6502 mL
10 mM 0.2825 mL 1.4125 mL 2.8251 mL
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