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Acetyl Tetrapeptide-5 Sale

(Synonyms: 眼丝氨肽;乙酰基四肽-5;丽眼肽) 目录号 : GC42702

A cosmeceutical matricin peptide

Acetyl Tetrapeptide-5 Chemical Structure

Cas No.:820959-17-9

规格 价格 库存 购买数量
250mg
¥1,696.00
现货
500mg
¥3,221.00
现货
1g
¥6,099.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Acetyl tetrapeptide-5 is a cosmeceutical matricin peptide.

Chemical Properties

Cas No. 820959-17-9 SDF
别名 眼丝氨肽;乙酰基四肽-5;丽眼肽
Canonical SMILES OC([C@@H](NC([C@H](CO)NC([C@@H](NC(CCNC(C)=O)=O)CC1=CN=CN1)=O)=O)CC2=CN=CN2)=O
分子式 C20H28N8O7 分子量 492.5
溶解度 PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0305 mL 10.1523 mL 20.3046 mL
5 mM 0.4061 mL 2.0305 mL 4.0609 mL
10 mM 0.203 mL 1.0152 mL 2.0305 mL
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Research Update

Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts

Skin Pharmacol Physiol 2021;34(4):194-202.PMID:33849044DOI:10.1159/000514496

Skin aging usually leads to the excessive deterioration of the dermal extracellular matrix, loss of antimicrobial function, loss of skin barrier function, and a series of inflammatory processes. Bioactive peptides have been widely used in cosmetics due to their protective effects on skin and efficient absorption. Combination of different peptides may lead to synergistic or antagonistic effects, so different formulas need to be designed and tested properly. In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments. After the individual activity test, the optimal concentration is 200 μg/mL of carnosine for the superoxide dismutase (SOD) activity, 200 μg/mL of GHK peptide for the hydroxyproline (HYP) content activity, 100 μg/mL of Acetyl Tetrapeptide-5 for the angiotensin-converting enzyme 1 activity, 400 μg/mL of hexapeptide-11 for the HYP content activity, and 400 μg/mL of acetyl hexapeptide-3 for the catecholamine content activity. According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts. One of the cosmeceutical peptide mixtures (carnosine + Acetyl Tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD and glutathione peroxidase. Our study suggests that this formula of cosmeceutical peptide mixtures could be a promising agent for use in anti-aging and protective cosmetics.