ACES
(Synonyms: N-(2-乙酰胺基)-2-氨基乙磺酸,N-(2-Acetamido)-2-aminoethanesulfonic acid) 目录号 : GC60553
ACES(N-(2-Acetamido)-2-aminoethanesulfonicacid)是一种两性离子缓冲剂。ACES缓冲液的工作pH范围是6.8-7.2。
Cas No.:7365-82-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
ACES (N-(2-Acetamido)-2-aminoethanesulfonic acid) is a zwitterionic buffer. The working pH range of ACES buffer is 6.8-7.2[1][2].
[1]. Melissa D Mertzman, et al. Effect of surfactant concentration and buffer selection on chromatographic figures of merit in chiral microemulsion electrokinetic chromatography. Electrophoresis. 2004 Oct;25(18-19):3247-56. [2]. Rabindra N Roy, et al. Buffer Standards for the Physiological pH of the Zwitterionic Compound, ACES from 5 to 55°C. J Solution Chem. 2009 Apr 1;38(4):471-483.
| Cas No. | 7365-82-4 | SDF | |
| 别名 | N-(2-乙酰胺基)-2-氨基乙磺酸,N-(2-Acetamido)-2-aminoethanesulfonic acid | ||
| Canonical SMILES | O=C(N)CNCCS(=O)(O)=O | ||
| 分子式 | C4H10N2O4S | 分子量 | 182.2 |
| 溶解度 | Water: 41.67 mg/mL (228.70 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.4885 mL | 27.4424 mL | 54.8847 mL |
| 5 mM | 1.0977 mL | 5.4885 mL | 10.9769 mL |
| 10 mM | 0.5488 mL | 2.7442 mL | 5.4885 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Intergenerational transmission and prevention of adverse childhood experiences (ACES)
Clin Psychol Rev 2021 Apr;85:101997.PMID:33689982DOI:10.1016/j.cpr.2021.101997.
In recent years, research and practice on adverse childhood experiences (ACES) have shifted from delineating effects of ACES on adulthood health problems to preventing ACES in children. Nonetheless, little attention has focused on how parents' own childhood experiences, adverse or positive, may influence the transmission of ACES across generations. Children's risk for ACES and potential for resilience may be linked to the early child-rearing experiences of their parents carried forward into parenting practices. Additionally, parents with multiple ACES may have PTSD symptoms, an under-recognized mediator of risk in the intergenerational transmission of ACES. Guided by developmental psychopathology and attachment theory with an emphasis on risk and resilience, we argue that a more comprehensive understanding of parents' childhood experiences is needed to inform prevention of ACES in their children. Part I of this review applies risk and resilience concepts to pathways of intergenerational ACES, highlighting parental PTSD symptoms as a key mediator, and promotive or protective processes that buffer children against intergenerational risk. Part II examines empirical findings indicating that parents' positive childhood experiences counteract intergenerational ACES. Part III recommends clinically-sensitive screening of ACES and positive childhood experiences in parents and children. Part IV addresses tertiary prevention strategies that mitigate intergenerational ACES and promote positive parent-child relationships.
Adverse Childhood Experiences (ACES), Stress and Mental Health in College Students
Stress Health 2018 Feb;34(1):36-45.PMID:28509376DOI:10.1002/smi.2761.
The goal of this short-term longitudinal study was to examine whether adverse childhood experiences (ACES) could be used to identify college students at risk for mental health problems and whether current level of stress mediates the relationship between ACES and mental health. Data on ACES and mental health (depression, anxiety and suicidality) were collected at the beginning of the semester, and data on current stressors and mental health were collected toward the end of the semester (n = 239). Findings indicated that ACES predicted worsening of mental health over the course of a semester and suggested current number of stressors as a mediator of the relationship between ACES and mental health. Results suggest that screening for ACES might be useful to identify students at high risk for deterioration in mental health. Results further suggest that stress-related interventions would be beneficial for students with high levels of ACES and point to the need for more research and strategies to increase help-seeking in college students.
Prevalence of adverse childhood experiences (ACES) among US children
Child Abuse Negl 2019 Jun;92:209-218.PMID:31003066DOI:10.1016/j.chiabu.2019.04.010.
Objective: The purpose of this study was to estimate the prevalence of adverse childhood experiences (ACES) among children in the United States and to examine the relationship between child and family characteristics and the likelihood of reported exposure to ACES. Methods: Data were drawn from the nationally representative 2016 National Survey of Children's Health (NSCH). Parent-reported child ACE exposure was measured using counts of those reporting zero ACES, one to three ACES, and four or more ACES. Results: The study sample included 45,287 children. The most prevalent types of ACE exposure experienced by children were economic hardship (22.5%) and parent or guardian divorce or separation (21.9%). Older children (34.7%), Non-Hispanic African American children (34.7%), children with special health care needs (SHCN; 36.3%), children living in poverty (37.2%), and children living in rural areas (30.5%) were more likely to be exposed to parental divorce or separation than their counterparts. Five cross-cutting factors emerged as important across outcomes: child's age, family structure, poverty, type of health insurance, and SHCN status. Conclusions: We found high prevalence rates of economic hardship on a national level. Our findings of higher prevalence among rural children further suggest the importance of the intersection of place and ACES. Therefore, the geographic component of ACES must be considered by policymakers. The identification of predictive factors related to high ACE exposure can inform early interventions at the national level.
ACES and counter-ACEs: How positive and negative childhood experiences influence adult health
Child Abuse Negl 2019 Oct;96:104089.PMID:31362100DOI:10.1016/j.chiabu.2019.104089.
Background: Numerous studies over the past two decades have found a link between adverse childhood experiences (ACES) and worse adult health outcomes. Less well understood is how advantageous childhood experiences (counter-ACEs) may lead to better adult health, especially in the presence of adversity. Objective: To examine how counter-ACEs and ACES affect adult physical and mental health using Resiliency Theory as the theoretical framework. Participants and setting: Participants were Amazon mTurk users ages 19-57 years (N = 246; 42% female) who completed an online survey. Methods: We conducted a series of regression analyses to examine how counter-ACEs and ACES predicted adult health. Results: Corresponding to the Compensatory Model of Resiliency Theory, higher counter-ACEs scores were associated with improved adult health and that counter-ACEs neutralized the negative impact of ACES on adult health. Contrary to the Protective Factors Model, there was a stronger relationship between ACES and worse adult health among those with above average counter-ACEs scores compared to those with below average counter-ACEs scores. Consistent with the Challenge Model, counter-ACEs had a reduced positive effect on adult health among those with four or more ACES compared to those with fewer than four ACES. Conclusions: Overall, the findings suggest that counter-ACEs protect against poor adult health and lead to better adult wellness. When ACES scores are moderate, counter-ACEs largely neutralize the negative effects of ACES on adult health. Ultimately, the results demonstrate that a public health approach to promoting positive childhood experiences may promote better lifelong health.
Adverse childhood experiences (ACES) and substance use disorder (SUD): A scoping review
Drug Alcohol Depend 2021 Apr 1;221:108563.PMID:33561668DOI:10.1016/j.drugalcdep.2021.108563.
Background: The long-term negative effects of adverse childhood experiences (ACES) and their impact on physical and mental health has been widely studied. However, research about the relationship between ACES and substance use disorder (SUD) diagnosis in adolescence and adulthood is still scarce. Therefore, this scoping review was conducted to collect the existing research findings to explore the relationship between the experience of ACES and the diagnosis of SUD later in life. Methods: The PsycINFO, Medline, Scopus, Web of Science, and Cochrane Library databases were searched. After identifying the records based on eligibility and exclusion criteria, 12 studies were finally selected for inclusion. Results: Most of the studies were conducted in the USA with adult male and female participants. All studies were cross-sectional in nature and assessed ACES retrospectively. The main conclusions of the studies were that there is a higher prevalence of ACES in the population with SUD than in the general population, and a positive association between ACES and the development and severity of SUD in adolescence and adulthood. Conclusions: It is difficult to make comparisons between studies and to draw solid conclusions because of the lack of standardized criteria for evaluating ACES and due to the heterogeneity in the substance types examined. More research is needed to fully elucidate the underlying mechanism of the relationship between ACES and SUD.