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5β-Dihydroprogesterone

(Synonyms: 5Β-二氢孕酮) 目录号 : GC49326

A progesterone receptor agonist and metabolite of progesterone

5β-Dihydroprogesterone Chemical Structure

Cas No.:128-23-4

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100 mg
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500 mg
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1 g
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产品描述

5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2 It is formed from progesterone by 5β-reductase.2 5β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 µg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAA receptor antagonist picrotoxin .1 It is a negative modulator of homooligomeric Ρ1 subunit-containing GABAA receptors, inhibiting GABA-induced currents in X. laevis oocytes expressing these receptors (IC50 = 5.02 µM).3 Plasma levels of 5β-DHP decrease at the onset of spontaneous human labor.4

1.Putnam, C.D., Brann, D.W., Kolbeck, R.C., et al.Inhibition of uterine contractility by progesterone and progesterone metabolites: Mediation by progesterone and gamma amino butyric acidA receptor systemsBiol. Reprod.45(2)266-272(1991) 2.Bumke-Vogt, C., BÄhr, V., Diederich, S., et al.Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidneyJ. Endocrinol.175(2)349-364(2002) 3.Morris, K.D., Moorefield, C.N., and Amin, J.Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroidsMol. Pharmacol.56(4)752-759(1999) 4.Sheehan, P.M., Rice, G.E., Moses, E.K., et al.5β-dihydroprogesterone and steroid 5β-reductase decrease in association with human parturition at termMol. Hum. Reprod.11(7)495-501(2005)

Chemical Properties

Cas No. 128-23-4 SDF
别名 5Β-二氢孕酮
Canonical SMILES C[C@@]12[C@]3([H])[C@](CC[C@]1([H])CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C
分子式 C21H32O2 分子量 316.5
溶解度 Chloroform: 30 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.1596 mL 15.7978 mL 31.5956 mL
5 mM 0.6319 mL 3.1596 mL 6.3191 mL
10 mM 0.316 mL 1.5798 mL 3.1596 mL
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