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5,7,8-Trimethoxyflavone Sale

(Synonyms: 5,7,8-三甲氧基黄酮,Norwogonin 5,7,8-trimethyl ether) 目录号 : GC60526

5,7,8-Trimethoxyflavone(Norwogonin5,7,8-trimethylether)来自于穿心莲,可以抑制NO,IC50为39.1μM。5,7,8-Trimethoxyflavone具有抗炎活性。

5,7,8-Trimethoxyflavone Chemical Structure

Cas No.:23050-38-6

规格 价格 库存 购买数量
5mg
¥1,620.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity[1].

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether; 8, 16, 32, 64 μM; for 24 hours) decreases NO production in a dose-dependent manner in RAW 264.7 macrophages. 5,7,8-Trimethoxyflavone does not change lipopolysaccharide (LPS)-induced (100 ng/mL) cell viability[1].

[1]. De-Yang Shen, et al. Chemical constituents from Andrographis echioides and their anti-inflammatory activity. Int J Mol Sci. 2012 Dec 27;14(1):496-514.

Chemical Properties

Cas No. 23050-38-6 SDF
别名 5,7,8-三甲氧基黄酮,Norwogonin 5,7,8-trimethyl ether
Canonical SMILES O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(OC)=CC(OC)=C13
分子式 C18H16O5 分子量 312.32
溶解度 储存条件 Store at -20°C
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1 mM 3.2018 mL 16.0092 mL 32.0184 mL
5 mM 0.6404 mL 3.2018 mL 6.4037 mL
10 mM 0.3202 mL 1.6009 mL 3.2018 mL
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Research Update

[Studies on flavonoids from Scutellaria moniliorrhiza]

Zhongguo Zhong Yao Za Zhi 2017 May;42(9):1699-1703.PMID:29082692DOI:10.19540/j.cnki.cjcmm.20170224.022.

By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, nineteen flavonoids were isolated and purified from the whole plants of Scutellaria moniliorrhiza. Based on the physico-chemical properties and spectral data, their structures were identified as: apigenin (1), luteolin (2), wogonin (3), oroxylin A (4), 6-methoxynaringein (5), 5,7,4'-trihydroxy-6,8-dimethoxyflavone (6), 5,7,8-Trimethoxyflavone (7), 3,5,6,7-tetramethoxyflavone (8), 7-hydroxy-4',5,6,8-tetramethoxyflavone (9), 5,7,2'-trihydroxy-6-methoxyflavanone (10), 5,7,4'-trihydroxy-6-methoxyflavone (11), 5,7-dihydroxy-6,8-dimethoxy -flavone (12), 5,2',6'-trihydroxy-7,8-dimethoxyflavone (13), 5,7,2'-trihydroxy-8-methoxyflavone (14), 5,2'-dihydroxy-7,8-dimethoxyflavanone (15), 2'-hydroxy-5,7,8-trimethoxyflavone (16), 5-hydroxy-7,8-dimethoxyflavone (17), 5,2'-dihydroxy-7,8-dimethoxyflavone (18), and 5-hydroxy-6,7,8-trimethoxyflavone (19). For the first time, compounds 1-19 were isolated from S. moniliorrhiza, and compounds 6, 8, 9, 12, 19 were isolated from the Scutellaria genus.