5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 uM. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone can significantly down-regulate the expression of estrogen receptor-α (ER-α) and inhibit tumor growth in human breast cancer cell line BCAP-37 xenograft model.
In vitro, We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro (with an IC50 of 4.41 μM)^[1].
In vivo, We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo^[1].

References:
[1]. FujiangGuo, et al. Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo. Phytochemistry Letters. 2013;6(3):331-336.

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 具有抗癌活性，体外对 ER 阳性乳腺癌MCF-7细胞表现出较强的抗增殖作用，对MCF-7细胞的IC50值为4.41 uM。5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 能显著下调雌激素受体-α (ER-α)的表达浓度，并能抑制人乳腺癌细胞系BCAP-37异种移植模型体内的肿瘤生长。
在体外，我们发现5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone在体外对ER阳性乳腺癌MCF-7细胞展现出强大的抑制增殖效果（IC50为4.41 μM）^[1]。
在体内，我们发现5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone显著降低了雌激素受体-α (ER-α) 的表达浓度，并能够在人乳腺癌细胞系BCAP-37的异种移植模型中抑制肿瘤生长^[1]。