4’-Hydroxyflavanone
(Synonyms: 4'-羟基黄烷酮) 目录号 : GC647634'-Hydroxyflavanone 是 SREBP 成熟和脂质合成的抑制剂。4'-Hydroxyflavanone 是黄酮的合成类似物,对肝脏脂肪变性和血脂异常具有潜在的研究价值。
Cas No.:6515-37-3
Sample solution is provided at 25 µL, 10mM.
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4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].
[1]. Shingo Miyata, et al. 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. FEBS Lett. 2012 Jun 21;586(13):1778-82.
Cas No. | 6515-37-3 | SDF | Download SDF |
别名 | 4'-羟基黄烷酮 | ||
分子式 | C15H12O3 | 分子量 | 240.25 |
溶解度 | DMSO : 100 mg/mL (416.23 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
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1 mg | 5 mg | 10 mg | |
1 mM | 4.1623 mL | 20.8117 mL | 41.6233 mL |
5 mM | 0.8325 mL | 4.1623 mL | 8.3247 mL |
10 mM | 0.4162 mL | 2.0812 mL | 4.1623 mL |
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2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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[Study on Fluorescence Properties of Flavanone and Its Hydroxyl Derivatives]
Guang Pu Xue Yu Guang Pu Fen Xi 2016 Apr;36(4):1007-12.PMID:30048098doi
Flavanone derivatives are important active ingredients of natural medicine, so the synthesis of these compounds is one of the research hotspots of organic synthesis. Nevertheless, there is little research on fluorescence properties of these compounds up to now. Fluorescence properties of flavanone and 6 kinds of hydroxyl derivatives are studied in this paper. It is found that aqueous solutions of flavanone (FV), 7-hydroxyflavanone (7HF) and 6-hydroxyflavanone (6HF) have fluorescence, but aqueous solutions of 2’-hydroxyflavanone (2’HF), 4’-Hydroxyflavanone (4’HF), naringenin and pinocembrin basically have no fluorescence. In three dimensional fluorescence spectra, excitation wavelengths λex of FV are located at 235, 265 and 340 nm, emission wavelength λem is at 386 nm; λex of 7HF are at 230, 276 and 315 nm, λem is at 391 nm; λex of 6HF are at 260 and 356 nm, em is at 482 nm. Influences of pH on fluorescence of FV, 7HF and 6HF are studied, and the reasons of pH affects on fluorescence are discussed from the viewpoint of molecular structure. The UV-absorption spectra of 7HF and 6HF at different pH are studied, and the proton ionization constants (pKa) of 7HF and 6HF are determined respectively to be 7.26±0.05 and 9.90±0.02, by a pH-absorption method. Influences of solvent (methanol) on fluorescence of FV, 7HF and 6HF are studied, and find that the fluorescence of FV and 7HF in methanol are weaker than that in water, but the fluorescence of 6HF in methanol is much stronger. In ordered media (SDS, CTAB and β-CD), fluorescence of FV and 7HF decreased than that in water, but the fluorescence of 6HF enhanced in the media of β-CD or CTAB. Using quinine sulfate or L-tryptophane as reference, fluorescence quantum yields of FV and 7HF aqueous solutions are measured to be 0.057 and 0.012, respectively; fluorescence quantum yields of 6HF in methanol or in aqueous solution containing 1.62 mg·mL-1 β-CD are measured to be 0.064 or 0.012, respectively.