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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Sale

(Synonyms: 4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉) 目录号 : GC46628

A building block and synthetic intermediate

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Structure

Cas No.:183322-18-1

规格 价格 库存 购买数量
25 mg
¥599.00
现货
50 mg
¥1,147.00
现货
100 mg
¥2,038.00
现货
250 mg
¥4,196.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5 It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3 It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5

1.Pandey, A., Volkots, D.L., Seroogy, J.M., et al.Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase familyJ. Med. Chem.45(17)3772-3793(2002) 2.Li, W.W., Wang, X.Y., Zheng, R.L., et al.Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3-morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivoJ. Med. Chem.55(8)3852-3866(2012) 3.Zhang, X., Su, M., Chen, Y., et al.The design and synthesis of a new class of RTK/HDAC dual-targeted inhibitorsMolecules18(6)6491-6503(2013) 4.Liu, Z., Wang, L., Feng, M., et al.New acrylamide-substituted quinazoline derivatives with enhanced potency for the treatment of EGFR T790M-mutant non-small-cell lung cancersBioorg. Chem.77593-599(2018) 5.Knesl, P., RÖseling, D., and Jordis, U.Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: Tandutinib, erlotinib and gefitinibMolecules11(4)286-297(2006)

Chemical Properties

Cas No. 183322-18-1 SDF
别名 4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉
Canonical SMILES ClC1=NC=NC2=C1C=C(OCCOC)C(OCCOC)=C2
分子式 C14H17ClN2O4 分子量 312.8
溶解度 DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1969 mL 15.9847 mL 31.9693 mL
5 mM 0.6394 mL 3.1969 mL 6.3939 mL
10 mM 0.3197 mL 1.5985 mL 3.1969 mL
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