3-hydroxy Carbofuran
(Synonyms: 3-羟基呋喃丹) 目录号 : GC41632
An active metabolite of carbofuran
Cas No.:16655-82-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-hydroxy Carbofuran is an active metabolite of carbofuran , which is an insecticide that inhibits acetylcholinesterase in mammals and insects. It is a metabolite formed in plants, insects, and mammals. 3-hydroxy Carbofuran has a half-maximal lethal concentration (LC50) value of 0.75 ppm in C. pipiens (mosquito) and an LD50 of greater than 500 mg/kg in M. domestica. It is considered an environmental toxin.
| Cas No. | 16655-82-6 | SDF | |
| 别名 | 3-羟基呋喃丹 | ||
| Canonical SMILES | CC1(C)OC2=C(OC(NC)=O)C=CC=C2C1O | ||
| 分子式 | C12H15NO4 | 分子量 | 237.3 |
| 溶解度 | Chloroform: Soluble,Methanol: Soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.2141 mL | 21.0704 mL | 42.1408 mL |
| 5 mM | 0.8428 mL | 4.2141 mL | 8.4282 mL |
| 10 mM | 0.4214 mL | 2.107 mL | 4.2141 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Residues of carbosulfan and its metabolites carbofuran and 3-hydroxy Carbofuran in rice field ecosystem in China
J Environ Sci Health B 2016;51(6):351-7.PMID:26963425DOI:10.1080/03601234.2015.1120606.
The fate of carbosulfan (seed treatment dry powder) was studied in rice field ecosystem, and a simple and reliable analytical method was developed for determination of carbosulfan, carbofuran, and 3-hydroxyl carbofuran in brown rice, rice straw, paddy water, and soil. The target compounds were extracted using acetonitrile or dichloromethane, cleaned up on acidic alumina or florisil solid phase extraction (SPE) cartridge, and analyzed by gas chromatography. The average recoveries of carbosulfan, carbofuran and 3-hydroxy Carbofuran in brown rice, rice straw, paddy water, and soil ranged from 72.71% to 105.07%, with relative standard deviations of 2.00-8.80%. The limits of quantitation (LOQs) of carbosulfan, carbofuran and 3-hydroxy Carbofuran in the samples (brown rice, rice straw, paddy water and soil) were 0.011, 0.0091, 0.014, 0.010 mg kg(-1), 0.016, 0.019, 0.025, 0.013 mg kg(-1), and 0.031, 0.039, 0.035, 0.036 mg kg(-1), respectively. The trials results showed that the half-lives of carbosulfan, carbofuran and 3-hydroxy Carbofuran in rice straw were 4.0, 2.6 days, 3.9, 6.0 days, and 5.8, 7.0 days in Zhejiang and Hunan, respectively. Carbosulfan, carbofuran and 3-hydroxy Carbofuran were detected in soils. Carbosulfan and 3-hydroxy Carbofuran were almost undetectable in paddy water. Carbofuran was detected in paddy water. The final residues of carbosulfan, carbofuran and 3-hydroxy Carbofuran in brown rice were lower than 0.05 mg kg(-1), which were lower than 0.5 mg kg(-1) (MRL of carbosulfan) or 0.1 mg kg(-1) (MRL of carbofuran). Therefore, a dosage of 420 g active ingredient per 100 kg seed was recommended, which could be considered as safe to human beings and animals. These would contribute to provide the scientific basis of using this insecticide.
Persistence and metabolism of carbofuran in the soil and sugarcane plant
Environ Monit Assess 2018 Aug 21;190(9):538.PMID:30132217DOI:10.1007/s10661-018-6926-6.
Persistence and metabolism of carbofuran in the soil and sugarcane plant were studied under tropical sugarcane ecosystem. Residues of carbofuran and its metabolites in the soil, sugarcane leaf, and juice were determined by employing matrix-specific sample preparation methods and gas chromatography equipped with mass spectrometry. The recoveries of carbofuran, 3-keto carbofuran, and 3-hydroxy Carbofuran were in the range of 88.75 ± 2.58-100.25 ± 2.38, 90.38 ± 2.61-98.24 ± 4.78, and 89.25 ± 3.11-98.10 ± 3.19%, respectively, at three levels of fortification across the three matrices involved in the study. At recommended dose (carbofuran 3% CG at 2 kg a.i./ha), the initial deposit of carbofuran in the soil was 14.390 ± 1.727 μg/g. The total residues comprising both carbofuran and 3-hydroxy Carbofuran were detected up to 105 days after treatment with the half-life of 10.83 days. The parent compound and its metabolite were detected and quantified in the sugarcane plant (leaves and juice) from 14 days after application of carbofuran in the soil. The total residues (carbofuran and 3-hydroxy Carbofuran) were detected in the leaves and cane juice up to 75 and 30 days after treatment, respectively.
Determination of carbofuran and its metabolites
J Chromatogr 1983 Jan 21;255:191-8.PMID:6863422DOI:10.1016/s0021-9673(01)88283-2.
High-performance liquid chromatographic (HPLC) methods for the determination of carbofuran and its metabolites are described. Results obtained for carrot samples by HPLC are compared with those obtained using gas chromatography and nitrogen-specific detection for carbofuran and 3-hydroxy Carbofuran and gas chromatography-mass spectrometry with selected ion monitoring for the determination of the three 7-phenol metabolites. The effect upon observed residue levels of conjugate formation by the 3-hydroxy and/or the 7-phenoxy groups of the four metabolites is demonstrated, and appropriate acid hydrolysis techniques are described. Variations in the HPLC parameters for different commodities are presented.
Degradation of carbofuran in water by solar photocatalysis in presence of photosensitizers
J Environ Sci Health B 2006;41(6):937-48.PMID:16893781DOI:10.1080/03601230600806137.
The effect of the presence of photosensitizers, methylene blue (MB) and rose Bengal (RB), on the degradation of carbofuran (2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate) in water in a solar photocatalytic system was investigated. It was found that as compared to MB, RB generally showed a stronger effect on the decomposition of carbofuran under comparable conditions. Among the conditions studied, adding 2 x 10(-6) M of RB, that corresponding to 2% of the initial concentration of carbofuran solution in the system, rendered the most effective degradation of carbofuran. As a result, a carbofuran removal percentage of 69.9%, a mineralization efficiency of 28.0%, and a microtoxicity reduction of 65.0% could be achieved. The degradation and mineralization of carbofuran was found to follow the pseudo-first order reaction kinetics. The decomposition mechanism of carbofuran was further investigated through identification of the intermediates to elaborate the influence of dye photosensitizer on the solar photocatalysis of carbofuran in water. On the basis of the intermediates identified, including carbofuran phenol, 3-hydroxy Carbofuran phenol, and substituted alcohols (3-phenoxy 1-propanol, 2-ethyl 1-hexanol, 2-butoxyl ethanol), it appears that hydrolysis and hydroxylation were the two key mechanisms for decomposing carbofuran during the process of solar photocatalysis with the aid of dye photosensitizer.
Carbofuran degraded by iron-doped anatase: Weakening the cholinesterase inhibitory activity in the photoproducts mixture
J Environ Sci Health B 2017 Aug 3;52(8):538-546.PMID:28494203DOI:10.1080/03601234.2017.1316161.
Carbofuran is a toxic carbamate pesticide, and its use has increased in recent years. While marketing information indicates stability in different chemical media, carbofuran exhibits relative photolability. The aim of this research was to decompose carbofuran and to identify the photoproducts achieved when two different doped titania photocatalysts were employed under UV irradiation. The iron-doped TiO2 materials were obtained (a) via a hydrothermal method and (b) by an ultrasound-assisted sol-gel method. The precursors were TiOSO4⋅xH2O and Fe3(NO3)·9H2O. X-ray studies confirmed that the anatase phase of the iron-doped TiO2 resulted from the two preparation methods. The photocatalytic performance of the prepared materials was monitored by LC/ESI-QTOF-MS, enabling the identification of photoproducts: oxo-carbamates, hydroxylated benzofuranes, a carboxamide, and one amine. By using the iron-doped TiO2 materials, 2,2-dimethyl-2,3-dihydrobenzofuran-3,7-diol was the most abundant photoproduct, and N,2,2-trimethyl-2,3-dihydrobenzofuran-7-amine was the only compound that had not been previously reported in the photolysis and photocatalysis of carbofuran. The product 3-hydroxy Carbofuran, a cholinesterase inhibitor, was quantified and was found to be transformed into compounds that lack this inhibitive property.