2H,2H,3H,3H-Perfluorooctanoic Acid
(Synonyms: 5:3 Fluorotelomer Carboxylic Acid, 5:3 FTCA) 目录号 : GC52258
2H,2H,3H,3H-perfluorooctanoic acid (5:3 FTCA)是一种全氟烷基化合物。
Cas No.:914637-49-3
Sample solution is provided at 25 µL, 10mM.
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2H,2H,3H,3H-Perfluorooctanoic acid (5:3 FTCA) is a perfluoroalkyl compound[1].
2H,2H,3H,3H-Perfluorooctanoic acid (5 mg; 48-144h) is a metabolite produced by the fungus Cunninghamella elegans during the biotransformation of 6:2 FTOH. Moreover, 2H,2H,3H,3H-Perfluorooctanoic acid, as the main metabolite, inhibits the activity of CYP enzymes, which are responsible for the biotransformation of 6:2 FTOH by Cunninghamella elegans[1].2H,2H,3H,3H-Perfluorooctanoic acid (10,000μg/L; 100 days) can be degraded by the aerobic bacterium Labrys portucalensis F11 (L. portucalensis F11) into PFHxA, PFPeA, PFBA, PFPrA, 5:3 fluorotelomer unsaturated carboxylic acid (5:3 FTUCA) and 7:2 fluorotelomer unsaturated carboxylic acid (7:2 FTUCA)[2].
References:
[1] Khan MF, Murphy CD. Fluorotelomer alcohols are efficiently biotransformed by Cunninghamella elegans. Environ Sci Pollut Res Int. 2023 Feb;30(9):23613-23623.
[2] Wijayahena MK, Moreira IS, Castro PML, Dowd S, Marciesky MI, Ng C, Aga DS. PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA. Sci Total Environ. 2025 Jan 10;959:178348.
2H,2H,3H,3H-perfluorooctanoic acid (5:3 FTCA)是一种全氟烷基化合物[1]。2H,2H,3H,3H-perfluorooctanoic acid (5mg; 48-144h)是真菌Cunninghamella elegans分解6:2 FTOH的代谢产物。并且2H,2H,3H,3H-perfluorooctanoic acid作为主要代谢产物，会抑制CYP酶（Cunninghamella elegans分解6:2 FTOH的酶）的活性[1]。2H,2H,3H,3H-Perfluorooctanoic acid（10,000μg/L; 100 天）可以被需氧细菌 Labrys portucalensis F11(L. portucalensis F11)降解为 PFHxA、PFPeA、PFBA、PFPrA、5:3 氟代烷基不饱和羧酸（5:3 FTUCA）和 7:2 氟代烷基不饱和羧酸(7:2 FTUCA)[2]。
| Cell experiment [1]: | |
Cell lines | L. portucalensis F11 |
Preparation Method | The biodegradation experiment of 2H,2H,3H,3H-Perfluorooctanoic acid by the L. portucalensis F11 strain was carried out under aerobic conditions in 250mL sealed flasks containing 50mL of minimal salts medium (MM) supplemented with 10,000μg/L of 2H,2H,3H,3H-Perfluorooctanoic acid. The cells of L. portucalensis F11 were inoculated at an optical density (OD) of approximately 0.05 at 600nm, and bacterial growth was monitored by measuring OD using a spectrophotometer. All cultures were incubated at 30°C on a rotary shaker (130rpm). The experiments were performed in duplicate under sterile conditions. The abiotic control assays included sealed flasks containing MM supplemented with 10,000μg/L of 2H,2H,3H,3H-Perfluorooctanoic acid, without bacterial inoculation. Additionally, three flasks with the same concentration of methanol but without the addition of 2H,2H,3H,3H-Perfluorooctanoic acid were set up as controls for cell growth. Samples were taken for analysis at 0, 48, 100 and 194 days to assess microbial growth and the biodegradation of 2H,2H,3H,3H-Perfluorooctanoic acid. The purity of the cultures was evaluated by regularly plating on nutrient agar (NA) plates. |
Reaction Conditions | 10,000μg/L; 0, 48, 100 and 194 days |
Applications | 2H,2H,3H,3H-Perfluorooctanoic acid (10,000μg/L; 100 days) can be degraded by the aerobic bacterium Labrys portucalensis F11 (L. portucalensis F11) into PFHxA, PFPeA, PFBA, PFPrA, 5:3 fluorotelomer unsaturated carboxylic acid (5:3 FTUCA), and 7:2 fluorotelomer unsaturated carboxylic acid (7:2 FTUCA). |
References: | |
| Cas No. | 914637-49-3 | SDF | Download SDF |
| 别名 | 5:3 Fluorotelomer Carboxylic Acid, 5:3 FTCA | ||
| Canonical SMILES | O=C(CCC(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)O | ||
| 分子式 | C8H5F11O2 | 分子量 | 342.1 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9231 mL | 14.6156 mL | 29.2312 mL |
| 5 mM | 0.5846 mL | 2.9231 mL | 5.8462 mL |
| 10 mM | 0.2923 mL | 1.4616 mL | 2.9231 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet