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22-HDHA Sale

(Synonyms: 22-hydroxy Docosahexaenoic Acid, 22-OH DHA) 目录号 : GC41210

An oxidation product of DHA

22-HDHA Chemical Structure

Cas No.:90780-46-4

规格 价格 库存 购买数量
25μg
¥4,112.00
现货
50μg
¥7,813.00
现货
100μg
¥14,801.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

22-HDHA is an oxidation product of docosahexaenoic acid . In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.

Chemical Properties

Cas No. 90780-46-4 SDF
别名 22-hydroxy Docosahexaenoic Acid, 22-OH DHA
Canonical SMILES OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
分子式 C22H32O3 分子量 344.5
溶解度 0.1 M Na2CO3: 2 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): 0.8 mg/ml 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9028 mL 14.5138 mL 29.0276 mL
5 mM 0.5806 mL 2.9028 mL 5.8055 mL
10 mM 0.2903 mL 1.4514 mL 2.9028 mL
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Research Update

Comprehensive Analysis of Fatty Acid and Oxylipin Patterns in n3-PUFA Supplements

J Agric Food Chem 2022 Apr 6;70(13):3979-3988.PMID:35324176DOI:10.1021/acs.jafc.1c07743

Supplementing long-chain omega-3 polyunsaturated fatty acids (n3-PUFA) improves health. We characterized the pattern of total and non-esterified oxylipins and fatty acids in n3 supplements made of fish, krill, or micro-algae oil by LC-MS. All supplements contained the declared amount of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); however, their content per capsule and the concentration of other fatty acids varied strongly. Krill oil contained the highest total n3 oxylipin concentration (6000 nmol/g) and the highest degree of oxidation (EPA 0.7%; DHA 1.3%), while micro-algae oil (Schizochytrium sp.) showed the lowest oxidation (<0.09%). These oils contain specifically high amounts of the terminal hydroxylation product of EPA (20-HEPE, 300 nmol/g) and DHA (22-HDHA, 200 nmol/g), which can serve as an authenticity marker for micro-algae oil. Refined micro-algae and fish oil were characterized by NEFA levels of ≤0.1%. Overall, the oxylipin and fatty acid pattern allows gaining new insights into the origin and quality of n3-PUFA oils in supplements.