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2-Thiouracil Sale

(Synonyms: 2-硫脲嘧啶; Thiouracil) 目录号 : GC12825

An antithyroid agent and a melanoma seeker

2-Thiouracil Chemical Structure

Cas No.:141-90-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥620.00
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50mg
¥525.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. Target: Others2-Thiouracil is an established antithyroid drug and an extensively investigated agent for the early detection and targeting of metastatic melanotic melanoma. In addition, 2-Thiouracil is also a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerization. Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure. Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase [1-3].

References:
[1]. Palumbo, A., M. d'Ischia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12.
[2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201.
[3]. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8.

Chemical Properties

Cas No. 141-90-2 SDF
别名 2-硫脲嘧啶; Thiouracil
化学名 2-sulfanylidene-1H-pyrimidin-4-one
Canonical SMILES C1=CNC(=S)NC1=O
分子式 C4H4N2OS 分子量 128.15
溶解度 ≥ 5.25mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 7.8034 mL 39.0168 mL 78.0336 mL
5 mM 1.5607 mL 7.8034 mL 15.6067 mL
10 mM 0.7803 mL 3.9017 mL 7.8034 mL
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