2-Amino-2-methyl-1,3-propanediol
目录号 : GC67463
2-Amino-2-methyl-1,3-propanediol 是一种固-固相变材料(PCMs)。2-Amino-2-methyl-1,3-propanediol 可用于制造表面活性剂、硫化促进剂和作为生物缓冲剂。
Cas No.:115-69-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2-Amino-2-methyl-1,3-propanediol is a solid-solid phase change materials (PCMs). Amino-2-methyl-1,3-propanediol can be used to make surfactants, vulcanization accelerators and as a biological buffer[1].
[1]. RyoheiGotoh, et al. Controlling heat release of crystallization from supercooling state of a solid-solid PCM, 2-amino-2-methyl-1,3-propanediol. International Journal of Heat and Mass Transfer, 2019, 1132-1140.
| Cas No. | 115-69-5 | SDF | Download SDF |
| 分子式 | C4H11NO2 | 分子量 | 105.14 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 9.5111 mL | 47.5556 mL | 95.1113 mL |
| 5 mM | 1.9022 mL | 9.5111 mL | 19.0223 mL |
| 10 mM | 0.9511 mL | 4.7556 mL | 9.5111 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dirhodium(II)-catalyzed C-H amination reaction of (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropyl carbamate: a facile preparation of optically active monoprotected 2-Amino-2-methyl-1,3-propanediol
Chem Pharm Bull (Tokyo) 2007 Sep;55(9):1385-9.PMID:17827768DOI:10.1248/cpb.55.1385.
Dirhodium(II)-catalyzed C-H amination reaction of (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropyl carbamate, which was easily prepared from methyl (S)-2-methyl-3-hydroxypropanoate, proceeded more smoothly than those of their 2-(methoxycarbonyl)propyl derivative to give the corresponding oxazolidinone in excellent yield. The resulting oxazolidinone was converted efficiently into both (R)-monoprotected and (S)-monoprotected 2-amino-2-methyl-1,3-propanediols.
DFT simulations and vibrational spectra of 2-Amino-2-methyl-1,3-propanediol
Spectrochim Acta A Mol Biomol Spectrosc 2014 Dec 10;133:214-22.PMID:24945862DOI:10.1016/j.saa.2014.04.152.
The FTIR and FT-Raman spectra of 2-Amino-2-methyl-1,3-propanediol were recorded in the regions 4000-400cm(-1) and 4000-50cm(-1) respectively. The structural and spectroscopic data of the molecule in the ground state were calculated using Hartee-Fock and density functional method (B3LYP) with the augmented-correlation consistent-polarized valence double zeta (aug-cc-pVDZ) basis set. The most stable conformer was optimized and the structural and vibrational parameters were determined based on this. The complete assignments were performed on the basis of the Potential Energy Distribution (PED) of the vibrational modes, calculated using Vibrational Energy Distribution Analysis (VEDA) 4 program. With the observed FTIR and FT-Raman data, a complete vibrational assignment and analysis of the fundamental modes of the compound were carried out. Thermodynamic properties and Mulliken charges were calculated using both Hartee-Fock and density functional method using the aug-cc-pVDZ basis set and compared. The calculated HOMO-LUMO energy gap revealed that charge transfer occurs within the molecule. (1)H and (13)C NMR chemical shifts of the molecule were calculated using Gauge-Independent Atomic Orbital (GIAO) method and were compared with experimental results.
A [Ce21] keplerate
Dalton Trans 2017 Jun 28;46(24):7677-7680.PMID:28590003DOI:10.1039/c7dt01883e.
The solvothermal reaction between Ce(NO3)3·6H2O, 2-amino-isobutyric acid, 2-hydroxy-1-naphthaldehyde and 2-Amino-2-methyl-1,3-propanediol in MeOH, in the presence of base, leads to the formation of a unique [CeCe ] keplerate cage.
The Influence of Selected Factors on the Aqueous Cryptotanshinone Solubility
Pharmaceutics 2021 Jun 30;13(7):992.PMID:34209049DOI:10.3390/pharmaceutics13070992.
The application of cryptotanshinone (CT), a diterpenoid obtained from the root of Salviae miltiorrhiza, is significantly hindered due to its poor aqueous solubility. The aim of the present research was to develop an optimal solvent for analytical and preparative procedures of prospective dermal hydrogel formulations with CT. The influence of pH, temperature, and cosolvent presence on the solubility of CT was examined. Various components were applied to increase CT solubility, i.e., ethanol, 2-Amino-2-methyl-1,3-propanediol, 2-amino-2-(hydroxymethyl)-1,3-propanediol, 2,2',2″-nitrilotriethanol, and triisopropanoloamine. The concentration of CT was analyzed by spectral and chromatographic methods, including UV-vis and HPLC methods. The increased solubility of CT was demonstrated in alkaline solvents with ethanol as a cosolvent. CT solutions doped with alcoholamines are more stable compared to CT solutions doped with NaOH.
Inorganic Approach to Stabilizing Nanoscale Toroidicity in a Tetraicosanuclear Fe18Dy6 Single Molecule Magnet
J Am Chem Soc 2020 Sep 2;142(35):14838-14842.PMID:32786752DOI:10.1021/jacs.0c07168.
Cyclic coordination clusters (CCCs) are proving to provide an extra dimension in terms of exotic magnetic behavior as a result of their finite but cyclized chain structures. The Fe18Dy6 CCC is a Single Molecule Magnet with the highest nuclearity among Ln containing clusters. The three isostructural compounds [Fe18Ln6(μ-OH)6(ampd)12(Hampd)12(PhCO2)24](NO3)6·38MeCN for Ln = DyIII (1), LuIII (2), or YIII (3), where H2ampd = 2-Amino-2-methyl-1,3-propanediol, are reported. These can be described in terms of the cyclization of six {Fe3Ln(μOH)(ampd)2(Hampd)2(PhCO2)4}+ units with six nitrate counterions to give the neutral cluster. The overall structure consists of two giant Dy3 triangles sandwiching a strongly antiferromagnetically coupled Fe18 ring, leading to a toroidal arrangement of the anisotropy axis of the Dy ions, making this the biggest toroidal arrangement on a molecular level known so far.