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15(R)-15-methyl Prostaglandin D2 Sale

(Synonyms: 15(R)15methyl PGD2) 目录号 : GC41164

A potent, selective agonist for the CRTH2/DP2 receptor

15(R)-15-methyl Prostaglandin D2 Chemical Structure

Cas No.:210978-26-0

规格 价格 库存 购买数量
500μg
¥1,010.00
现货
1mg
¥1,918.00
现货
5mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.

Chemical Properties

Cas No. 210978-26-0 SDF
别名 15(R)15methyl PGD2
Canonical SMILES CCCCC[C@@](C)(O)\C=C\[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O
分子式 C21H34O5 分子量 366.5
溶解度 DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >5 mg/ml (from PGD2) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7285 mL 13.6426 mL 27.2851 mL
5 mM 0.5457 mL 2.7285 mL 5.457 mL
10 mM 0.2729 mL 1.3643 mL 2.7285 mL
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