11S(12R)-EET
(Synonyms: 11S(12R)-EpETrE; 11S(12R)-epoxy-5(Z),8(Z),14(Z)-ETrE; 11S(12R)-epoxy-all-cis-5,8,14-Eicosatrienoic Acid; 11S(12R)-Epoxyeicosatrienoic Acid; FA 20:4;O) 目录号 : GC9270311S(12R)-EET is an oxylipin and a metabolite of arachidonic acid .
Cas No.:123931-40-8
Sample solution is provided at 25 µL, 10mM.
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11S(12R)-EET is an oxylipin and a metabolite of arachidonic acid . It is selectively formed from arachidonic acid by the cytochrome P450 (CYP) isoform CYP2B2 over CYP2C23 and CYP2C24, as well as CYP2C9 over CYP2C8. 11S(12R)-EET (50 nM) activates large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells. It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 20 pM) and denuded porcine subepicardial arterioles (EC50 = 10 pM). Unlike 11R(12S)-EET , 11S(12R)-EET does not inhibit the epithelial sodium channel (ENaC) in a patch-clamp assay using isolated rat cortical collecting duct tubules or induce migration of human umbilical vein endothelial cells (HUVECs).
| Cas No. | 123931-40-8 | SDF | |
| 别名 | 11S(12R)-EpETrE; 11S(12R)-epoxy-5(Z),8(Z),14(Z)-ETrE; 11S(12R)-epoxy-all-cis-5,8,14-Eicosatrienoic Acid; 11S(12R)-Epoxyeicosatrienoic Acid; FA 20:4;O | ||
| 化学名 | 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-5Z,8Z-decadienoic acid | ||
| Canonical SMILES | CCCCC/C=C\C[C@@H]1[C@@H](O1)C/C=C\C/C=C\CCCC(O)=O | ||
| 分子式 | C20H32O3 | 分子量 | 320.5 |
| 溶解度 | Acetonitrile: Sparingly soluble: 1-10 mg/ml; Ethanol: Slightly soluble: 0.1-1 mg/ml | 储存条件 | -20°C |
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1201 mL | 15.6006 mL | 31.2012 mL |
| 5 mM | 624 μL | 3.1201 mL | 6.2402 mL |
| 10 mM | 312 μL | 1.5601 mL | 3.1201 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet