1-Naphthoic Acid
(Synonyms: 1-萘甲酸) 目录号 : GC41217
1-Naphthoic acid is used as an intermediate for the synthesis of various compounds.
Cas No.:86-55-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Naphthoic acid is used as an intermediate for the synthesis of various compounds.
| Cas No. | 86-55-5 | SDF | |
| 别名 | 1-萘甲酸 | ||
| Canonical SMILES | O=C(C1=CC=CC2=C1C=CC=C2)O | ||
| 分子式 | C11H8O2 | 分子量 | 172.2 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.8072 mL | 29.036 mL | 58.072 mL |
| 5 mM | 1.1614 mL | 5.8072 mL | 11.6144 mL |
| 10 mM | 0.5807 mL | 2.9036 mL | 5.8072 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Triphenylphosphine oxide-1-naphthoic acid (1/1)
Acta Crystallogr C 2004 Jul;60(Pt 7):o531-2.PMID:15237188DOI:10.1107/S010827010401279X.
In the title compound, C18H15OP.C11H8O2, co-crystallization of triphenylphosphine oxide with 1-Naphthoic Acid yields a supramolecular structure held together by one O-H...O and three C-H...O hydrogen bonds. The O-H...O hydrogen bond [O...O = 2.592 (2) A] has little effect on the O=P bond distance.
Redetermination of the structures of 1-Naphthoic Acid and 2-naphthoic acid
Acta Crystallogr C 1993 Nov 15;49 ( Pt 11):1952-8.PMID:8280434DOI:10.1107/s0108270193002641.
The structures of 1-Naphthoic Acid and 2-naphthoic acid have been investigated in order to determine the degree of disorder of the carboxylic acid groups. 1-Naphthoic Acid was found to be completely ordered with C--O bond lengths of 1.214 (3) and 1.312 (3) A, and C--C--O bond angles of 124.8 (2) and 114.2 (2) degrees. 2-Naphthoic acid was found to possess a significant degree of disorder with C--O bond lengths of 1.256 (3) and 1.274 (3) A, and C--C--O bond angles of 117.7 (2) and 119.1 (2) degrees. In 2-naphthoic acid, the acid H atom was refined at two sites with 0.5 occupancy at each. Analysis of the anisotropic displacement ellipsoids of the acid O atoms for each structure demonstrated that these parameters are consistent with thermal motion of the O atoms. These results indicated that the proton, but not the O atoms, is disordered in the carboxylic acid group of 2-naphthoic acid. In each structure, the acid molecules form cyclic dimers about inversion centers, with an O...O(acceptor) distance of 2.653 (3) in 1-Naphthoic Acid and 2.618 (3) A in 2-naphthoic acid. The cyclic dimers form layers in each of these structures wherein lateral closest intermolecular approaches to the acid O atoms are from ring H atoms. The intermolecular O...H close approaches, together with the intramolecular close approaches, are very uniform in distance and angle of approach for the two O atoms in the 2-naphthoic acid structure.(ABSTRACT TRUNCATED AT 250 WORDS)
A pathway for biodegradation of 1-Naphthoic Acid by Pseudomonas maltophilia CSV89
Arch Microbiol 1995 Jan;163(1):42-7.PMID:7710320DOI:10.1007/BF00262202.
Pseudomonas maltophilia CSV89, a bacterium isolated from soil in our laboratory, grows on 1-Naphthoic Acid as the sole source of carbon and energy. To elucidate the pathway for degradation of 1-Naphthoic Acid, the metabolites were isolated from spent medium, purified by TLC, and characterized by gas chromatography-mass spectrometry. The involvement of various metabolites as intermediates in the pathway was established by demonstrating relevant enzyme activities in cell-free extracts, oxygen uptake and transformation of metabolites by the whole cells. The results obtained from such studies suggest that the degradation of 1-Naphthoic Acid is initiated by double hydroxylation of the aromatic ring adjacent to the one bearing the carboxyl group, resulting in the formation of 1,2-dihydroxy-8-carboxynaphthalene. The resultant diol was oxidized via 3-formyl salicylate, 2-hydroxyisophthalate, salicylate and catechol to TCA cycle intermediates.
Development of a novel naphthoic acid ionic liquid and its application in "no-organic solvent microextraction" for determination of triclosan and methyltriclosan in human fluids and the method optimization by central composite design
Talanta 2016 Jul 1;154:381-91.PMID:27154690DOI:10.1016/j.talanta.2016.03.092.
In traditional ionic liquids (ILs)-based microextraction, the hydrophobic and hydrophilic ILs are often used as extractant and disperser, respectively. However, the functional effects of ILs are not utilized in microextraction procedures. Herein, we introduced 1-Naphthoic Acid into imidazolium ring to synthesize a novel ionic liquid 1-butyl-3-methylimidazolium naphthoic acid salt ([C4MIM][NPA]), and its structure was characterized by IR, (1)H NMR and MS. On the basis of its acidic property and lower solubility than common [CnMIM][BF4], it was used as a mixing dispersive solvent with [C4MIM][BF4] in "functionalized ionic liquid-based no organic solvent microextraction (FIL-NOSM)". Utilization of [C4MIM][NPA] in FIL-NOSM procedures has two obvious advantages: (1) it promoted the non-polar environment, increased volume of the sedimented phase, and thus could enhance the extraction recoveries of triclosan (TCS) and methyltriclosan (MTCS) by more than 10%; and (2) because of the acidic property, it can act as a pH modifier, avoiding extra pH adjustment step. By combining single factor optimization and central composite design, the main factors in the FIL-NOSM method were optimized. Under the optimal conditions, the relative recoveries of TCS and MTCS reached up to 98.60-106.09%, and the LODs of them were as low as 0.12-0.15µgL(-1) in plasma and urine samples. In total, this [C4MIM][NPA]-based FIL-NOSM method provided high extraction efficiency, and required less pretreatment time and unutilized any organic solvent. To the best of our knowledge, this is the first application of [C4mim][NPA]-based microextraction method for the simultaneous quantification of trace TCS and MTCS in human fluids.
Novel intermediates of acenaphthylene degradation by Rhizobium sp. strain CU-A1: evidence for naphthalene-1,8-dicarboxylic acid metabolism
Appl Environ Microbiol 2006 Sep;72(9):6034-9.PMID:16957226DOI:10.1128/AEM.00897-06.
The acenaphthylene-degrading bacterium Rhizobium sp. strain CU-A1 was isolated from petroleum-contaminated soil in Thailand. This strain was able to degrade 600 mg/liter acenaphthylene completely within three days. To elucidate the pathway for degradation of acenaphthylene, strain CU-A1 was mutagenized by transposon Tn5 in order to obtain mutant strains deficient in acenaphthylene degradation. Metabolites produced from Tn5-induced mutant strains B1, B5, and A53 were purified by thin-layer chromatography and silica gel column chromatography and characterized by mass spectrometry. The results suggested that this strain cleaved the fused five-membered ring of acenaphthylene to form naphthalene-1,8-dicarboxylic acid via acenaphthenequinone. One carboxyl group of naphthalene-1,8-dicarboxylic acid was removed to form 1-Naphthoic Acid which was transformed into salicylic acid before metabolization to gentisic acid. This work is the first report of complete acenaphthylene degradation by a bacterial strain.