Triacetonamine
(Synonyms: 四甲基哌啶酮; 2,2,6,6-Tetramethyl-4-piperidone) 目录号 : GC38963
TriacetonaMine (Tempidon, Tmpone, Odoratine, Vincubine), a member of the class of compounds known as piperidinones, is an extremely weak acidic compound found in green vegetables and tea.
Cas No.:826-36-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
TriacetonaMine (Tempidon, Tmpone, Odoratine, Vincubine), a member of the class of compounds known as piperidinones, is an extremely weak acidic compound found in green vegetables and tea.
| Cas No. | 826-36-8 | SDF | |
| 别名 | 四甲基哌啶酮; 2,2,6,6-Tetramethyl-4-piperidone | ||
| Canonical SMILES | O=C1CC(C)(C)NC(C)(C)C1 | ||
| 分子式 | C9H17NO | 分子量 | 155.24 |
| 溶解度 | Ethanol: 50 mg/mL (322.08 mM) | 储存条件 | Store at 2-8°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.4416 mL | 32.2082 mL | 64.4164 mL |
| 5 mM | 1.2883 mL | 6.4416 mL | 12.8833 mL |
| 10 mM | 0.6442 mL | 3.2208 mL | 6.4416 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Triacetonamine formation in a bio-oil from fast pyrolysis of sewage sludge using acetone as the absorption solvent
Bioresour Technol 2010 Jun;101(11):4242-5.PMID:20137920DOI:10.1016/j.biortech.2010.01.031.
A sewage sludge sample was pyrolyzed in a drop tube furnace at 500 degrees C and sweeping gas flow rate of 300cm(3)/min. Triacetonamine (TAA) was detected with GC/MS as major component in the resulting bio-oil using acetone as the absorption solvent and proven to be a product from the reaction of NH(3) in the bio-oil with the absorption solvent acetone. TAA yield increased with storage time and reached a level about 28.4% (% sludge fed, daf) after 175h. Since the reaction of pure NH(3) with acetone does not proceed, some species in the bio-oil must catalyze the reaction of NH(3) with acetone. TAA was isolated in a high yield (27.9%, daf) and high purity (80.4%) by column chromatography with different solvents, including mixed solvents, as eluants. The study revealed the possibility of sewage sludge as potential resource of TAA.
Theoretical models for the conformations and the protonation of Triacetonamine
J Comput Aided Mol Des 1990 Dec;4(4):403-9.PMID:1965442DOI:10.1007/BF00117405.
In this paper we propose theoretical models for the conformations of Triacetonamine and protonated Triacetonamine (Vincubine, an anticancer chemotherapeutic agent) developed by quantum and molecular mechanics techniques. We discuss the theoretical factors which are involved in the stabilization of the conformations calculated by the MNDO, MM2 and COPEANE methods and show the relative percent abundance of each molecular shape. Graphic representations of the conformers are depicted.
Nutrient and bioactive compounds composition of the leaves and stems of Pandiaka heudelotii: A wild vegetable
Heliyon 2019 Apr 15;5(4):e01501.PMID:31025012DOI:10.1016/j.heliyon.2019.e01501.
The proximate, minerals, vitamins, amino acid, alkaloids, phytosterols, carotenoids, glycosides and saponins profiles of the leaves and stems of Pandiaka heudelotii were determined using standard methods. The leaves and stems had high contents (g/100g) of fibre (10.3-12.9) and carbohydrate (47.2-55.3); and moderate protein (4.4-9.8) and crude fat (6.7-10.2); respectively, equivalent to 41.1-51.6%, 15.7-17.8%, 8.8-19.6%, 10.3-15.7% of the corresponding daily values. They had high contents of iron, manganese, calcium, magnesium, potassium, selenium, vitamins C, E and B2, alkaloids, glycosides, carotenoids, saponins; and moderate phytosterol. Their proteins had high contents of essential amino acids (42.6-48.5%). Triacetonamine (57.20-60.13%), nicotiflorin (53.45-55.35%), carotene (49.95-51.94%), liquiritin (57.54-62.34%), and sitosterol (82.84-85.03%) were respectively, the most abundant alkaloids, glycosides, carotenoids, saponins and phytosterols detected. This result indicates that the leaves and stems are good sources of nutraceuticals and nutrients for human nutrition. It provides an insight into the nature of its bioactive components.
Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia
Curr Cancer Drug Targets 2018;18(4):365-371.PMID:28669342DOI:10.2174/1568009617666170623104030.
Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice, and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents. Method: Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation, Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity, acute toxicity techniques were used in this study. Results: Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated using in vitro activities and in vivo methods and found significant results. These compounds possess iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from Triacetonamine (1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1- methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine < Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to 1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate toxicity which increases with increasing lipophility, but not excite at 400 mg/kg. Conclusion: It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide with CHA in most cases result in the appearance of a considerable anti-tumor effect of cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by the CHA derivatives of Valine 1c or 2c.
Effects of piperazine derivatives on the activity of frog skeletal muscle fibers
Gen Pharmacol 1995 Oct;26(6):1431-9.PMID:7590143DOI:10.1016/0306-3623(94)00235-f.
1. This study was undertaken to characterize the effects of some piperazine derivatives on excitable cell membranes. Three original Bulgarian compounds with favorable effects on cardiovascular and nervous system--piperazine derivatives with code names P-11 (N1-[3-oxo-3-phenyl-2-methyl-propyl]-N4-[trans-3-hydroxy-1,2,3,4- tetrahydro-2-naphthyl]-piperazine dihydrochloride), AS2 (N1-benzhydryl-N4-allyl piperazine dihydrochloride) and 35-M (Schiff's base of N1-benzhydryl-N4-aminopiperazine with Triacetonamine, dioxalate salt) were tested in experiments with conventional microelectrode technique on isolated frog muscle fibers. 2. After 30-min treatment with tested drugs at concentrations of 10-100 microM the recorded intra-(ICAP) and extracellular action potentials (ECAPs) showed an amplitude decrease and duration increase. The total ionic current (Ii) decreased as the outward phase was almost abolished by P-11. The propagation velocity (PV) of excitation and the twitch amplitude also decreased. These changes were agent- and concentration-dependent. 3. The effect potency of the agents diminished in the following order: P-11 > AS2 > 35-M. 4. Concentrations higher than 100 microM for all agents completely, but reversibly, inhibited membrane excitability. 5. The results demonstrate compound- and concentration-induced modulation of Ca2+ current with blockade of Ca(2+)-dependent K+ and Cl- membrane channels of muscle fiber treated with the compound tested.