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Home >> Signaling Pathways >> MAPK Signaling >> MAP3K

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

Products for  MAP3K

  1. Cat.No. 产品名称 Information
  2. GC69984 TAK1-IN-4 TAK1-IN-4 (Compound 14) 是一种 TAK1 抑制剂。
  3. GC63144 PF-05381941 PF-05381941 是一种有效的 TAK1/p38α 双抑制剂，IC50 值分别为 156 和 186 nM。
  4. GC49150 Tpl2 Kinase Inhibitor (hydrochloride) A Tpl2 inhibitor
  5. GC62675 SM1-71 SM1-71 是一种有效的 TAK1 抑制剂，Ki 值为 160 nM，同时可以共价抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 在体外抑制多种癌细胞系的增殖。
  6. GC62497 TAK1-IN-2 TAK1-IN-2 是一种有效和选择性的 TAK1 抑制剂，IC50> 值为 2 nM。
  7. GC62426 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM.
  8. GC35735 Cot inhibitor-2 Cot 抑制剂-2是COT/Tpl2抑制剂。
  9. GC35734 Cot inhibitor-1 Cot 抑制剂-1是COT/Tpl2抑制剂。
  10. GC45067 Tpl2 Kinase Inhibitor A Tpl2 inhibitor
  11. GC32687 Takinib A TAK1 inhibitor
  12. GC30913 DLK-IN-1 DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。
  13. GC19173 GNE-3511 A selective and highly potent inhibitor of DLK
  14. GC19041 ASK1-IN-1 ASK1-IN-1 是一种有效的、口服的、选择性的 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50 为 2.87 nM。
  15. GC12124 Selonsertib (GS-4997) An ASK1 inhibitor
  16. GC14853 TC ASK 10 A inhibitor of ASK1
  17. GC13944 (5Z)-7-Oxozeaenol A selective TAK1 inhibitor
  18. GC17577 NQDI 1 A selective inhibitor of ASK1
  19. GC13514 NG25 An inhibitor of MAP4K2 and TAK1
  20. GC12151 B-Raf inhibitor B-Raf inhibitor 是一种有效的双重 TGFβ-activated kinase 1 (TAK1) 和 mitogen-activated protein kinase kinase kinase 2 (MAP4K2) 抑制剂，IC50 分别为 41.1 nM 和 18.2 nM。

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