Protein Ser/Thr Phosphatases(蛋白质丝氨酸/苏氨酸磷酸酶)
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
Products for Protein Ser/Thr Phosphatases
- Cat.No. 产品名称 Information
- GC15974 bpV(HOpic) (potassium salt, technical grade) A PTEN inhibitor
- GC15969 PTP Inhibitor IV An active-site directed inhibitor of protein tyrosine phosphatases
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GC11806
β-Glycerophosphate (sodium salt hydrate)
An inhibitor of alkaline phosphatase
- GC16900 PRL-3 Inhibitor An inhibitor of PTP4A3
- GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
- GC15120 PTP Inhibitor I A SHP-1(ΔSH2) and PTP1B inhibitor
- GC15804 PTP Inhibitor II A SHP-1(ΔSH2) inhibitor
- GC13442 Sanguinarine chloride A natural alkaloid with anti-inflammatory and anti-oxidant properties
- GC12498 Sephin1 A selective inhibitor of the phosphatase regulatory subunit PPP1R15A
- GC12189 LB-100 A PP2A inhibitor with anticancer activity
- GC11561 NSC 95397 An irreversible inhibitor of Cdc25 isoforms
-
GC11381
Tautomycetin
Tautomycetin 是一种有效的特异性 PP1 抑制剂,具有潜在的细胞凋亡诱导活性。
- GC14875 NSC 663284 Inhibitor of Cdc25 isoforms
- GC16290 Nafamostat hydrochloride Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂,是一种抗凝剂。
- GC17676 Nafamostat A serine protease inhibitor
- GC12891 CCT007093 An inhibitor of PPM1D
- GC15718 CID 2011756 An inhibitor of protein kinase D
- GC12020 TCS 401 A selective PTP1B inhibitor
- GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
- GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases
- GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic
- GC14321 Sal 003 An inhibitor of eIF2α dephosphorylation
- GC16958 Okadaic acid A potent inhibitor of protein phosphatases
- GC17966 NFAT Inhibitor A peptide inhibitor of NFAT
- GC16117 INCA-6 A cell-permeant inhibitor of NFAT signaling
-
GC12604
Fumonisin B1
A mycotoxin
- GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4
- GC14024 DL-AP3 A metabotropic glutamate receptor antagonist
- GC17011 C2 Ceramide A cell-permeable analog of naturally occurring ceramides
- GC18106 Calyculin A Potent inhibitor of PP1 and PP2A
- GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂,IC50 为 ~10 μM。