|Geranylgeranyl Pyrophosphate (ammonium salt) 目录号 GC43747|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||313263-08-0||SDF||Download SDF|
|溶解度||A solution in methanol:ammonium hydroxide (70:30)||储存条件||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids. It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases. This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.
. Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).
. McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006).
. Baron, R.A., and Seabra, M.C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal 415(1), 67-75 (2008).
. Maynor, M., Scott, S.A., Rickert, E.L., et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters 18(6), 1889-1892 (2008).