Neoglycyrol
(Synonyms: 甘草酚) 目录号 : GC36718A coumestan
Cas No.:23013-84-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >97.00%
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Neoglycyrol is a coumestan that has been found in G. uralensis.1
1.Tao, W.-W., Duan, J.-A., Yang, N.-Y., et al.Antithrombotic phenolic compounds from Glycyrrhiza uralensisFitoterapia83(2)422-425(2012)
Cas No. | 23013-84-5 | SDF | |
别名 | 甘草酚 | ||
Canonical SMILES | O=C1C2=C(OC3=CC(O)=CC=C32)C4=C(OC)C(C/C=C(C)\C)=C(O)C=C4O1 | ||
分子式 | C21H18O6 | 分子量 | 366.36 |
溶解度 | Soluble in DMSO | 储存条件 | 4°C, protect from light |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.7296 mL | 13.6478 mL | 27.2956 mL |
5 mM | 0.5459 mL | 2.7296 mL | 5.4591 mL |
10 mM | 0.273 mL | 1.3648 mL | 2.7296 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill]
Zhejiang Da Xue Xue Bao Yi Xue Ban 2015 Mar;44(2):145-53.PMID:26038132DOI:10.3785/j.issn.1008-9292.2015.03.005.
Objective: Based on cell model and HPLC-MS technology, to screen myocardial protection active compounds from traditional patent medicine Tongmai Yangxin pill (TMYXP). Methods: Fractions of TMYXP were prepared by high performance liquid preparation technology. The cardioprotective effects of prepared fractions were tested on H2O2 oxidation-damaged H9c2 myocardiocytes. The active components were analyzed by high performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry. The possible active compounds were putatively identified by comparison of their MS ions and molecular weight with literatures. Results: Ten TMYXP components presented significant myocardial protective activities, 5 of which were investigated and presented good dose-effect relationships. Their median effective concentrations (EC50) were respectively 11.66, 17.44, 13.10, 7.332, 15.15 μg/mL. Totally, 11 potential active compounds were analyzed and identified, including Glycyrrhizic acid, Glycycoumarin, Licoisoflavone, Ophiopogonin D', Licoricon, Gancaonin L, Neoglycyrol, Emodin, Angeloylgomisin H, Angeloylgomisin Q and Glyasperin A. Conclusion: The myocardial protection active compounds of TMYXP were screened successfully.
[Chemical studies of coumarins from Glycyrrhiza uralensis Fisch]
Yao Xue Xue Bao 1991;26(2):147-51.PMID:1950571doi
This paper reports the isolation and identification of eight crystalline substances (I, II, III, IV, V, VI, VII, VIII) from the root of Glycyrrhiza uralensis Fisch. Besides the known compounds liquiritin, hexacosance, beta-sitosterol, licoricone liquiritigenin and etc, a new constituent, named Neoglycyrol was obtained by sillica gel and polyamide column chromatographic method. Its chemical structure was elucidated by means of chemical and spectrometric analysis (UV, IR, NMR and MS). Neoglycyrol, C21H18O6, yellow needles with mp 263.5-265 degrees C, possesses one methoxyl, one isopentenyl and two hydroxyls. Its diacetate derivative is C25H22O8 with mp 202-203.5 degrees C. Its dimethyl ether derivative is C23H22O6 with mp 207-208.5 degrees C. Its structure was found to be VII.