Choline-d9 (chloride) |
目录号 GC49856 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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Purity: >99.00%
- COA (Certificate Of Analysis)
- Datasheet
Choline-d9 is intended for use as an internal standard for the quantification of choline by GC- or LC-MS. Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis.1,2,3,4 It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport.1 Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats.2 Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm.3 Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.4
1.Sanders, L.M., and Zeisel, S.H.Choline: Dietary requirements and role in brain developmentNutr. Today42(4)181-186(2007) 2.Thomas, J.D., Garrison, M., and O’Neill, T.M.Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in ratsNeurotoxicol. Teratol.26(1)35-45(2004) 3.Derbyshire, E., and Obeid, R.Choline, neurological development and brain function: A systematic review focusing on the first 1000 daysNutrients12(6)1731(2020) 4.Moretti, A., Paoletta, M., Liguori, S., et al.Choline: An essential nutrient for skeletal muscleNutrients12(7)E2144(2020)
Cas No. | 61037-86-3 | SDF | Download SDF |
别名 | N/A | ||
化学名 | N/A | ||
Canonical SMILES | [2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-] | ||
分子式 | C5H5D9NO ? Cl | 分子量 | 148.7 |
溶解度 | DMSO: slightly soluble,Ethanol: 2 mg/ml,PBS (pH 7.2): 2 mg/ml | 储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % ddH2O | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。