Chloramphenicol
(Synonyms: 氯霉素) 目录号 : GC15185
An acetylated version of chloramphenicol
Cas No.:56-75-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chloramphenicol is a broad-spectrum antibiotic against bacterial infections.
References:
[1]. Jardetzky, O., Studies on the mechanism of action of chloramphenicol. I. The conformation of chlioramphenicol in solution. J Biol Chem, 1963. 238: p. 2498-508.
[2]. Wolfe, A.D. and F.E. Hahn, Mode of Action of Chloramphenicol. Ix. Effects of Chloramphenicol Upon a Ribosomal Amino Acid Polymerization System and Its Binding to Bacterial Ribosome. Biochim Biophys Acta, 1965. 95: p. 146-55.
| Cas No. | 56-75-7 | SDF | |
| 别名 | 氯霉素 | ||
| 化学名 | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide | ||
| Canonical SMILES | C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] | ||
| 分子式 | C11H12Cl2N2O5 | 分子量 | 323.13 |
| 溶解度 | ≥ 16.16 mg/mL in DMSO, ≥ 16.25 mg/mL in Water with ultrasonic and warming, ≥ 33 mg/mL in EtOH | 储存条件 | Store at 2-8°C,unstable in solution, ready to use. |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0947 mL | 15.4736 mL | 30.9473 mL |
| 5 mM | 0.6189 mL | 3.0947 mL | 6.1895 mL |
| 10 mM | 0.3095 mL | 1.5474 mL | 3.0947 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Chloramphenicol
IARC Monogr Eval Carcinog Risks Hum 1990;50:169-93.2292798 PMC7682317
Chloramphenicol
Med Clin North Am 1982 Jan;66(1):91-102.7038343 10.1016/s0025-7125(16)31444-4
Chloramphenicol
Pediatr Clin North Am 1968 Feb;15(1):57-72.4866907 10.1016/s0031-3955(16)32088-0
Chloramphenicol toxicity
Adverse Drug React Toxicol Rev 1993 Summer;12(2):83-95.8357947
Although high serum concentrations of Chloramphenicol are related to toxicity, as shown experimentally and during treatment, the mechanism of toxicity remains unclear. Published work suggests that relatively minor metabolites may be causally related to toxic reactions in vitro and some of these metabolites have been detected in sera from treated patients. It is possible that all the major toxic manifestations of Chloramphenicol may be explained by attack by free radicals. Depletion in compounds acting as cellular antioxidants, such as glutathione and vitamin E, may conceivably increase the vulnerability of an individual to Chloramphenicol toxicity, while supplementation with an antioxidant might protect against it. Research into the metabolism of Chloramphenicol and into the mechanism of its toxicity has declined since early work in the 1950s and 1960s, but its continuing use worldwide means that there is justification for renewed interest in the toxicology of this useful antibiotic.
Chloramphenicol: what we have learned in the last decade
South Med J 1986 Sep;79(9):1129-34.3529436
Chloramphenicol is a unique antibiotic. The kinetics and efficacy of the oral and intravenous preparations are comparable. Chloramphenicol is usually bacteriostatic but is bactericidal against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis, and Chloramphenicol's clinical efficacy against these meningeal pathogens is well established. Chloramphenicol can be used to treat serious pediatric infections when Haemophilus influenzae is a likely pathogen, as well as typhoid fever, anaerobic infections, bacterial meningitis in patients allergic to penicillin, brain abscesses, and rickettsial infections. The use of Chloramphenicol is limited because of its toxicity. Aplastic anemia is very rare but can occur after either oral or intravenous administration. The gray syndrome can be eliminated and marrow suppression minimized by using Chloramphenicol at the recommended doses and monitoring levels. During the last decade the increased use of Chloramphenicol has not resulted in increased resistance or in frequent reports of toxicity. Thus, Chloramphenicol remains an important inpatient antibiotic that can be invaluable for treating certain life-threatening infections.