C18 3'-sulfo Galactosylceramide-d3 (d18:1/18:0-d3)
(Synonyms: N-Octadecanoyl Sulfatide-d3, N-ω-CD3-Octadecanoyl-sulfatide) 目录号 : GC46985
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
C18 3'-sulfo Galactosylceramide-d3 is intended for use as an internal standard for the quantification of C18 3'-sulfo galactosylceramide by GC- or LC-MS. C18 3'-sulfo Galactosylceramide is a minor endogenous sphingolipid produced from C18 ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus.1 It is found in pro-oligodendroblasts and in neurons and accumulates in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency.2,1,3 C18 3'-sulfo Galactosylceramide also increases expression of indoleamine 2,3-dioxygenase 1 (DOX1) to catalyze the initial and rate-limiting step in kynurenine pathway tryptophan catabolism in antigen presenting cells to regulate several immune responses.1 [Matreya, LLC. Catalog No. 1536]
1.Takahashi, T., and Suzuki, T.Role of sulfatide in normal and pathological cells and tissuesJ. Lipid Res.53(8)1437-1450(2012) 2.Saville, J.T., Smith, N.J.C., Fletcher, J.M., et al.Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophyAnal. Chim. Acta95579-85(2017) 3.Svennerholm, L., and StÄllberg-Stenhagen, S.Changes in the fatty acid composition of cerebrosides and sulfatides of human nervous tissue with ageJ. Lipid Res.9(2)215-225(1968)
| Cas No. | N/A | SDF | |
| 别名 | N-Octadecanoyl Sulfatide-d3, N-ω-CD3-Octadecanoyl-sulfatide | ||
| Canonical SMILES | O[C@@H]1[C@@H](OS(O)(=O)=O)[C@@H](O)[C@@H](CO)O[C@H]1OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC | ||
| 分子式 | C42H78D3NO11S | 分子量 | 811.2 |
| 溶解度 | Chloroform:Methanol:Water (2:1:0.1): soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2327 mL | 6.1637 mL | 12.3274 mL |
| 5 mM | 0.2465 mL | 1.2327 mL | 2.4655 mL |
| 10 mM | 0.1233 mL | 0.6164 mL | 1.2327 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。