2,3-Butanediol
(Synonyms: 2,3-丁二醇) 目录号 : GC60458
2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on.
Cas No.:513-85-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on.
| Cas No. | 513-85-9 | SDF | |
| 别名 | 2,3-丁二醇 | ||
| Canonical SMILES | CC(O)C(O)C | ||
| 分子式 | C4H10O2 | 分子量 | 90.12 |
| 溶解度 | DMSO: 100 mg/mL (1109.63 mM); Water: 100 mg/mL (1109.63 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 11.0963 mL | 55.4816 mL | 110.9632 mL |
| 5 mM | 2.2193 mL | 11.0963 mL | 22.1926 mL |
| 10 mM | 1.1096 mL | 5.5482 mL | 11.0963 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Microbial production of 2,3-Butanediol for industrial applications
J Ind Microbiol Biotechnol 2019 Nov;46(11):1583-1601.PMID:31468234DOI:10.1007/s10295-019-02231-0.
2,3-Butanediol (2,3-BD) has great potential for diverse industries, including chemical, cosmetics, agriculture, and pharmaceutical areas. However, its industrial production and usage are limited by the fairly high cost of its petro-based production. Several bio-based 2,3-BD production processes have been developed and their economic advantages over petro-based production process have been reported. In particular, many 2,3-BD-producing microorganisms including bacteria and yeast have been isolated and metabolically engineered for efficient production of 2,3-BD. In addition, several fermentation processes have been tested using feedstocks such as starch, sugar, glycerol, and even lignocellulose as raw materials. Since separation and purification of 2,3-BD from fermentation broth account for the majority of its production cost, cost-effective processes have been simultaneously developed. The construction of a demonstration plant that can annually produce around 300 tons of 2,3-BD is scheduled to be mechanically completed in Korea in 2019. In this paper, core technologies for bio-based 2,3-BD production are reviewed and their potentials for use in the commercial sector are discussed.
Metabolic engineering of non-pathogenic microorganisms for 2,3-Butanediol production
Appl Microbiol Biotechnol 2021 Aug;105(14-15):5751-5767.PMID:34287658DOI:10.1007/s00253-021-11436-2.
2,3-Butanediol (2,3-BDO) is a promising commodity chemical with various industrial applications. While petroleum-based chemical processes currently dominate the industrial production of 2,3-BDO, fermentation-based production of 2,3-BDO provides an attractive alternative to chemical-based processes with regards to economic and environmental sustainability. The achievement of high 2,3-BDO titer, yield, and productivity in microbial fermentation is a prerequisite for the production of 2,3-BDO at large scales. Also, enantiopure production of 2,3-BDO production is desirable because 2,3-BDO stereoisomers have unique physicochemical properties. Pursuant to these goals, many metabolic engineering strategies to improve 2,3-BDO production from inexpensive sugars by Klebsiella oxytoca, Bacillus species, and Saccharomyces cerevisiae have been developed. This review summarizes the recent advances in metabolic engineering of non-pathogenic microorganisms to enable efficient and enantiopure production of 2,3-BDO. KEY POINTS: • K. oxytoca, Bacillus species, and S. cerevisiae have been engineered to achieve efficient 2,3-BDO production. • Metabolic engineering of non-pathogenic microorganisms enabled enantiopure production of 2,3-BDO. • Cost-effective 2,3-BDO production can be feasible by using renewable biomass.
Bioengineering for the industrial production of 2,3-Butanediol by the yeast, Saccharomyces cerevisiae
World J Microbiol Biotechnol 2022 Jan 12;38(3):38.PMID:35018511DOI:10.1007/s11274-021-03224-x.
Owing to issues, such as the depletion of petroleum resources and price instability, the development of biorefinery related technologies that produce fuels, electric power, chemical substances, among others, from renewable resources is being actively promoted. 2,3-Butanediol (2,3-BDO) is a key compound that can be used to produce various chemical substances. In recent years, 2,3-BDO production using biological processes has attracted extensive attention for achieving a sustainable society through the production of useful compounds from renewable resources. With the development of genetic engineering, metabolic engineering, synthetic biology, and other research field, studies on 2,3-BDO production by the yeast, Saccharomyces cerevisiae, which is safe and can be fabricated using an established industrial-scale cultivation technology, have been actively conducted. In this review, we sought to describe 2,3-BDO and its derivatives; discuss 2,3-BDO production by microorganisms, in particular S. cerevisiae, whose research and development has made remarkable progress; describe a method for separating and recovering 2,3-BDO from a microbial culture medium; and propose future prospects for the industrial production of 2,3-BDO by microorganisms.
Prospects on bio-based 2,3-Butanediol and acetoin production: Recent progress and advances
Biotechnol Adv 2022 Jan-Feb;54:107783.PMID:34098005DOI:10.1016/j.biotechadv.2021.107783.
The bio-based platform chemicals 2,3-Butanediol (BDO) and acetoin have various applications in chemical, cosmetics, food, agriculture, and pharmaceutical industries, whereas the derivatives of BDO could be used as fuel additives, polymer and synthetic rubber production. This review summarizes the novel technological developments in adapting genetic and metabolic engineering strategies for selection and construction of chassis strains for BDO and acetoin production. The valorization of renewable feedstocks and bioprocess development for the upstream and downstream stages of bio-based BDO and acetoin production are discussed. The techno-economic aspects evaluating the viability and industrial potential of bio-based BDO production are presented. The commercialization of bio-based BDO and acetoin production requires the utilization of crude renewable resources, the chassis strains with high fermentation production efficiencies and development of sustainable purification or conversion technologies.
Lignocellulosic bio-refinery approach for microbial 2,3-Butanediol production
Bioresour Technol 2020 Apr;302:122873.PMID:32019707DOI:10.1016/j.biortech.2020.122873.
Bio-refinery approach using agricultural and industrial waste material as feedstock is becoming a preferred area of interest in biotechnology in the current decades. The reasons for this trend are mainly because of the declining petroleum resources, greenhouse gas emission risks and fluctuating market price of crude oil. Most chemicals synthesized petro chemically, can be produced using microbial biocatalysts. 2,3-Butanediol (BDO) is such an important platform bulk chemical with numerous industrial applications including as a fuel additive. Although microbial production of BDO is well studied, strategies that could successfully upgrade the current lab-scale researches to an industrial level have to be developed. This review presents an overview of the recent trends and developments in the microbial production of BDO from different lignocellulose biomass.