Home>>Signaling Pathways>> Cell Cycle/Checkpoint>> Cytoskeleton & Motor Proteins>>YK-3-237

YK-3-237

目录号 : GC18578

An inhibitor of tubulin polymerization and activator of SIRT1

YK-3-237 Chemical Structure

Cas No.:1215281-19-8

规格 价格 库存 购买数量
1mg
¥246.00
现货
5mg
¥1,066.00
现货
10mg
¥1,951.00
现货
25mg
¥3,615.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

YK-3-237 is a chalcone derivative and an activator of sirtuin 1 (SIRT1).[1],[2] It inhibits colchicine binding to tubulin in a concentration-dependent manner and tubulin polymerization (IC50 = 31 μM) and induces microtubule loss in A-10 cells (EC50 = 16.5 μM).[1] YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = <0.01-20.9 μM). It inhibits tube formation by human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 μM and inhibits functional angiogenesis in isolated rat aortic rings. YK-3-237 activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner.[2] It also inhibits cell growth in panel of 9 triple-negative breast cancer (TNBC) cell lines (EC50s = 0.160-5.031 μM).

Reference:
[1]. Kong, Y., Wang, K., Edler, M.C., et al. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. Bioorg. Med. Chem. 18(2), 971-977 (2010).
[2]. Yi, Y.W., Kang, H.J., Kim, H.J., et al. Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4(7), 984-994 (2013).

Chemical Properties

Cas No. 1215281-19-8 SDF
化学名 B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid
Canonical SMILES COC1=C(OC)C(OC)=CC(C(/C=C/C2=CC(B(O)O)=C(OC)C=C2)=O)=C1
分子式 C19H21BO7 分子量 372.2
溶解度 30mg/mL in DMSO, 30mg/mL in DMF, 10mg/mL in Ethanol 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.6867 mL 13.4336 mL 26.8673 mL
5 mM 0.5373 mL 2.6867 mL 5.3735 mL
10 mM 0.2687 mL 1.3434 mL 2.6867 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置