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(+)-Usniacin Sale

(Synonyms: (+)-地衣酸) 目录号 : GC17330

(+)-Usniacin 从地衣中分离出来,结合在 mTOR 的 ATP 结合口袋,并抑制 mTORC1/2 活性。 (+)-Usniacin 抑制 mTOR 下游效应子的磷酸化:Akt (Ser473)、4EBP1、S6K,诱导自噬,具有抗癌活性。 (+)-Usniacin 对许多浮游革兰氏阳性菌具有抗菌活性,包括金黄色葡萄球菌、粪肠球菌和粪肠球菌。

(+)-Usniacin Chemical Structure

Cas No.:7562-61-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥378.00
现货
10mg
¥389.00
现货
50mg
¥830.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

MIC: 0.05 μg/62.5 μl to 3.1 μg/62.5 μl

Microorganisms can colonize a wide variety of medical devices, putting patients at risk for systemic and local infectious complications, including local-site infections, endocarditis, and catheter-related bloodstream infections. (+)-Usniacin is a secondary lichen metabolite that possesses antimicrobial activity against various planktonic gram-positive bacteria.

In vitro: (+)-Usniacin showed antimicrobial activity against the same microorganisms as that of acetone extract. Among the three analogues it was the most active one having quite low MIC values. Furthermore, (+)-Usniacin did not show any activity against A. hydrophila and B. cereus whereas (D)-usnic acid did. On the other hand, (+)-Usniacin was active against Y. enterocolitica whereas (D)-usnic acid was not active [1].

In vivo: No animal in-vivo study has been reproted so far.

Clinical trials: Trials carried out in volunteers showed that mouth-rinse with (+)-Usniacin preparations exerted a selective and long lasting action against S. mutans. The adherence of S. mutans to smooth surfaces was not increased by the presence of subinhibiting concentrations of (+)-Usniacin. These characteristics make (+)-Usniacin a suitable candidate for topical use in oral medicine [2].

References:
[1] Tay T, Türk AO, Yilmaz M, Türk H, Kivanç M.  Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents. Z Naturforsch C. 2004 May-Jun;59(5-6):384-8.
[2] Ghione M, Parrello D, Grasso L.   Usnic acid revisited, its activity on oral flora. Chemioterapia. 1988 Oct;7(5):302-5.

Chemical Properties

Cas No. 7562-61-0 SDF
别名 (+)-地衣酸
Canonical SMILES CC1=C(C(=C2C(=C1O)C3(C(=CC(=C(C3=O)C(=O)C)O)O2)C)C(=O)C)O
分子式 C18H16O7 分子量 344.32
溶解度 ≥ 8.0mg/mL in DMSO with gentle warming 储存条件 4°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.9043 mL 14.5214 mL 29.0428 mL
5 mM 0.5809 mL 2.9043 mL 5.8086 mL
10 mM 0.2904 mL 1.4521 mL 2.9043 mL
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