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UNC 3230 目录号 GC13054

PIP5K1C inhibitor

规格 价格 库存 购买数量
1mg
¥494.00
现货
5mg
¥1,235.00
现货
10mg
¥2,223.00
现货
50mg
¥8,645.00
现货
500mg
¥49,350.00
现货
1g
¥79,800.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

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Chemical Properties

Cas No. 1031602-63-7 SDF
别名 N/A
化学名 5-(cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
Canonical SMILES NC(C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1)=O
分子式 C17H20N4O2S 分子量 344.43
溶解度 0.2mg/mL in ethanol, 30mg/mL in DMSO, or in DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).[1] Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.[1] UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).[1] It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.[1] At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.[1]

Reference:
[1]. Wright, B.D., Loo, L., Street, S.E., et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82(4), 836-847 (2014).