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UAMC-3203 hydrochloride Sale

目录号 : GC34939

A ferroptosis inhibitor

UAMC-3203 hydrochloride Chemical Structure

Cas No.:2271358-65-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥795.00
现货
5mg
¥711.00
现货
10mg
¥1,170.00
现货
50mg
¥1,890.00
现货
100mg
¥2,655.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells.1 It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 ?mol/kg. It is not toxic to mice following chronic administration of a 20 ?mol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.

1.Devisscher, L., Van Coillie, S., Hofmans, S., et al.Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacyJ. Med. Chem.61(22)10126-10140(2018)

Chemical Properties

Cas No. 2271358-65-5 SDF
Canonical SMILES O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O.Cl
分子式 C25H38ClN5O2S 分子量 508.12
溶解度 DMSO : 50 mg/mL (98.40 mM) 储存条件 4°C, away from moisture and light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.968 mL 9.8402 mL 19.6804 mL
5 mM 0.3936 mL 1.968 mL 3.9361 mL
10 mM 0.1968 mL 0.984 mL 1.968 mL
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