Home>>type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]

type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]

目录号 GP10050

type I hair keratin

规格 价格 库存 购买数量
1mg
¥347.00
现货
5mg
¥1,071.00
现货
10mg
¥1,911.00
现货
25mg
¥2,583.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

The human type I hair keratin subfamily comprises nine individual members, which can be subdivided into three groups. Group A (hHa1, hHa3-I, hHa3-II, hHa4) and B (hHa7, hHa8) each contains structurally related hair keratins, whereas group C members hHa2, hHa5, and hHa6 represent structurally rather unrelated hair keratins1.

Keratins are divided into type I (acidic) and type II (basic to neutral) members, which form the 10-nm intermediate filament cytoskeletal network of epithelial cells through obligatory association of equimolar amounts of type I and type II keratins2,3,4.

The various type I hair keratin antibodies proved to be highly specific in that they recognized only single protein bands when analyzed in Western blots of one dimensionally resolved human hair keratins. One exception concerned the hHa2 antibody, which besides the prominent hHa2 protein band also reacted with a slightly larger minor band1. . A LEF-1 consensus sequence is invariably located at a highly conserved position in the proximal promoter region of the members of the human type I hair keratin family but it is specifically lacking in the entire promoter of the hHa7 gene5.

References:
1. L. Langbein, M. A. Rogers et al. The Catalog of Human Hair Keratins. The journal of biological chemistry. 274: 19874-19884, 1999
2.Steinert, P. M., and Roop, D. R. (1988) Annu. Rev. Biochem. 57, 593-625.
3.Fuchs, E., and Weber, K. (1994) Annu. Rev. Biochem. 63, 345-382.
4.Mischke, D. (1998) in Intermediate Filaments: Subcellular Biochemistry (Herrmann, H., and Harris, J. R., eds) Vol. 31, pp. 71-95, Plenum Press, New York.
5.Rogers, M. A., Winter, H., Wolf, C., Jacobs, M., and Schweizer, J. (1998)J. Biol. Chem. 273, 26683-26691.

Chemical Properties

Cas No. N/A SDF
别名 H2N-Leu-Asn-Asp-Arg-Leu-Ala-Ser-Tyr-Leu-OH
化学名 N/A
Canonical SMILES NC(CC(C)C)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C)C(NC(CO)C(NC(CC1=CC=C(O)C=C1)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C47H77N13O15 分子量 1064.19
溶解度 ≥ 106.4mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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