Tedizolid-13C-d3

Tedizolid-¹³C-d₃ is intended for use as an internal standard for the quantification of tedizolid by GC- or LC-MS. Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate .¹ Tedizolid phosphate is converted to tedizolid by phosphatases in vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistant S. aureus (MRSA), E. faecalis, and penicillin-susceptible S. pneumoniae (MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptible S. aureus (MSSA) infection (ED₅₀ = 8.8 mg/kg).²

1.Schaadt, R., Sweeney, D.A., Shinabarger, D., et al.In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agentAntimicrob. Agents Chemother.53(8)3236-3239(2009) 2.Im, W.B., Choi, S.H., Park, J.-Y., et al.Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agentEur. J. Med. Chem.46(4)1027-1039(2011)