Sodium Lauryl Sulfoacetate
(Synonyms: 月桂醇磺基乙酸酯钠) 目录号 : GC48085
An anionic surfactant
Cas No.:1847-58-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sodium lauryl sulfoacetate is an anionic surfactant.1 It increases proliferation of isolated chicken peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 62.5 to 500 µg/ml.2 Sodium lauryl sulfoacetate (1, 2, and 4 mg/kg) increases the blood CD4+ to CD8+ T cell ratio induced by a Newcastle disease virus vaccine in chickens. Formulations containing sodium lauryl sulfoacetate have been used as surfactants in the manufacture of cosmetics.
1.Gad, E.A.M., El-Sukkary, M.M.A., and Azzam, E.M.S.Surface and thermodynamic properties of octyl, dodecyl, and cetyl sulfoacetatesMonatshefte fÜr Chemie1281085-1092(1997) 2.Cheng, D., Zhu, S., and Sun, H.The immune enhancement of sodium lauryl sulfoacetate in chickensVet. Med. Int.485060(2010)
| Cas No. | 1847-58-1 | SDF | |
| 别名 | 月桂醇磺基乙酸酯钠 | ||
| Canonical SMILES | CCCCCCCCCCCCOC(CS([O-])(=O)=O)=O.[Na+] | ||
| 分子式 | C14H27O5S.Na | 分子量 | 330.4 |
| 溶解度 | DMSO : 2mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0266 mL | 15.1332 mL | 30.2663 mL |
| 5 mM | 0.6053 mL | 3.0266 mL | 6.0533 mL |
| 10 mM | 0.3027 mL | 1.5133 mL | 3.0266 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The immune enhancement of Sodium Lauryl Sulfoacetate in chickens
Vet Med Int 2010;2010:485060.PMID:20454644DOI:10.4061/2010/485060.
The purpose of this study is to investigate feasibility of Sodium Lauryl Sulfoacetate (SLS) as an immunoadjuvant in chickens. After treating with 62.5, 125, 250, or 500 mug/mL SLS in vitro, lymphocyte proliferation assay of chicken peripheral blood mononuclear cells showed that the OD(570) values of all experimental groups, as well as Con A-stimulated group, were significantly higher than that of the untreated control group. After injection with 1.0, 2.0, or 4.0 mg/kg of SLS for 3 consecutive days, chickens were vaccinated with an attenuated vaccine against Newcastle disease virus (NDV), and the immunoadjuvant effects of SLS were evaluated on the basis of immune organ index, antibody response, and CD(4) (+)/CD(8) (+) T-cell ratio. The results confirmed that SLS could enhance NDV-specific antibody response and increase CD(4) (+)/CD(8) (+) T-cell ratio in vivo. Furthermore, SLS could improve NDV-specific antibody response in thiamphenicol-treated chickens. These data indicate that SLS not only can improve humoral immune response but also reverse the immunosuppressive effect of thiamphenicol in chickens.
Effectiveness of Acupuncture for Management in a Hospitalized Geriatric Patient with Constipation
Med Acupunct 2020 Apr 1;32(2):116-120.PMID:32351665DOI:10.1089/acu.2019.1401.
Background: Constipation is a gastrointestinal problem commonly found in clinical practice. The prevalence increases with age. Chronic constipation is associated with a decrease in patients' quality of life (QoL). Existing treatments cause side-effects and the positives effects are only short-term. Recently, acupuncture has been widely used to treat geriatric problems, and one of the problems being addressed is constipation. Case: An 85-year-old female, with hip fractures, had episodes of being unable to defecate and had stomach pain that was persistent due to this constipation. She was admitted to the hospital for her fractures, where manual acupuncture was used to treat her constipation. Results: The therapy was effective for relieving the patient's stomach pain and constipation, and increased the patient's appetite as well as improving her QoL. Conclusions: Stomach pain in geriatric patients with constipation can lead to difficulty in sleeping, loss of appetite, and persistent pain in the stomach. Constipation can be assessed by using posterior anterior and oblique views of the abdominal radiographic projection. Numerous modalities, including pharmacologic therapy (Sodium Lauryl Sulfoacetate enema and lactulose syrup), have been used to treat constipation-related pain. Recently, acupuncture has also been used to treat stomach pain in geriatric patients with constipation. Acupuncture was effective for relieving the current patient's pain and constipation and also improved her QoL.