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Simufilam hydrochloride Sale

(Synonyms: PTI-125 hydrochloride) 目录号 : GC63193

Simufilam (PTI-125) (hydrochloride) 是一种低毒的,具有口服活性的 filamin A (FLNA) 激活剂。Simufilam (hydrochloride) 可优先结合改变的 FLNA,并恢复其天然构象,恢复受体和突触活性,并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam (hydrochloride) 可用于阿尔茨海默症的研究。

Simufilam hydrochloride Chemical Structure

Cas No.:2480226-07-9

规格 价格 库存 购买数量
1mg
¥588.00
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5mg
¥1,470.00
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10mg
¥2,330.00
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25mg
¥3,930.00
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50mg
¥5,720.00
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100mg
¥7,970.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer’s disease[1].

Simufilam (1 pM~1 nM) (hydrochloride) dose-dependently improves NMDA/glycine-induced Arc expression[1].Simufilam (1 nM, 1 hour) (hydrochloride) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam (hydrochloride) dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam (hydrochloride) reduces Ab42’s binding affinity for a7nAChR, thereby prevents Ab42’s signaling and further accumulation on a7nAChRs[1].

Simufilam (P.o.; 2 months) (hydrochloride) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) (hydrochloride) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam (hydrochloride) significantly improves spatial memory. Simufilam (hydrochloride) significantly improves working memory[1].

[1]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer’s disease pathogenesis. Neurobiol Aging. 2017;55:99-114.

Chemical Properties

Cas No. 2480226-07-9 SDF
别名 PTI-125 hydrochloride
分子式 C15H22ClN3O 分子量 295.81
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.3805 mL 16.9027 mL 33.8055 mL
5 mM 0.6761 mL 3.3805 mL 6.7611 mL
10 mM 0.3381 mL 1.6903 mL 3.3805 mL
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